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Table 1 Effect of Epoxomicin on AA Release from Rat Glial, Human Colon Carcinoma and Human Breast Carcinoma Cells.

From: Proteasome inhibitors: Their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells

Cell Type % AA Release
  MEM/BSA control With epoxomicin
Rat glial (C-6) 9.0 ± 0.07 11.4 ± 0.28
Human Colon Carcinoma (HT-29) 7.8 ± 0.05 9.4 ± 0.33
Human Breast Carcinoma (BT-20) 12.1 ± 0.35 14.2 ± 0.31
  1. Cells were incubated in the presence and absence of 4.5 μM epoxomicin for 6-h, 12-h or 9-h (C-6, HT-29, BT-20 respectively). Analyses were performed with quadruplicate (C-6 and HT-29) or quintuplicate (BT-20) dishes. All values are expressed as Mean ± SE (n = 4 or n = 5). All data with epoxomicin are statistically significant vs MEM/BSA.