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Table 1 Inhibitory actions of pregabalin on voltage-activated calcium currents.

From: A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats

Peak control current amplitude (nA)

Pregabalin Concentration (μM)

Peak current in the presence of pregabalin (nA)

Percentage inhibition and n value

-1.52 ± 0.13

0.025

-0.98 ± 0.12 **

31 ± 4 % (n = 8)

-1.2 ± 0.14

0.25

-0.93 ± 0.18 *

22 ± 9 % (n = 6)

-1.19 ± 0.11

2.5

-0.94 ± 0.09***

21 ± 3 % (n = 26)

  1. ***P < 0.001; **P < 0.01 and *P < 0.05. Each value is given ± S.E.M. Data shows inhibition but a lack of dose-dependent actions on ICa of a wide range of pregabalin concentrations. Although varied responses were observed it was clear that a major component of ICa was resistant to inhibition by pregabalin.
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BMC Pharmacology

ISSN: 1471-2210