Table 1 Dose-response shapes for functional-HOTSM, when varying b, b·d, and A S . AM, a, L, and c are fixed (AM = 1, a = 100, L = 1/30, c < 1). With AS < 1 at high agonist concentrations, the second HOTSM response level is below the start level when b < 1, Fig 5A and B, and above when b > 1, Fig 5C and D.
b | b·d | AS > 1 | AS < 1 | Fig |
|---|---|---|---|---|
<1 | >1 | terraced, mono-phasic | mono-phasic, reverse bell-shaped | 5A |
<1 | =1 | mono-phasic | mono-phasic, reverse bell-shaped | - |
<1 | =0.5 | bell-shaped, mono-phasic | mono-phasic, reverse bell-shaped | - |
<1 | <0.5 | bell-shaped | bell-shaped, mono-phasic, reverse bell-shaped | 5B & Fig 2B |
>1 | <0.5 | bell-shaped | bell-shaped, mono-phasic, terraced | 5D |
>1 | =0.5 | bell-shaped | bell-shaped | - |
>1 | =1 | mono-phasic, terraced | terraced | - |
>1 | >1 | terraced | terraced | 5C |
, mono-phasic, terraced
For a >>b the bell-shape disappears and becomes mono-phasic.