Figure 4

Examples of varying parameter d for the functional-HOTSM dose-responses. Panel A, parameter d is varied in five steps increasing by a factor 10 from 5 × 10^-3 (—) to 5 × 10¹ (-..-..-..) with the other parameters fixed as indicated. Panel B is a 3 dimensional plot of separately changing the ligand concentration at either the orthosteric site, "O", the modulator site, "M", or simultaneously at both sites. Such 3-D plots are relevant for the switch from the HOTSM to the ATSM. Notice that a = 10 is below b = 100, and compare with figure 3B.