From: The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes
 | peak area (AU × s × 104) | |||
---|---|---|---|---|
 | incubation time (h) | |||
 | 2 | 4 | 8 | 24 |
 | 25 μM | |||
UM-1 | - | - | - | 10.0 ± 0.6 |
UM-2 | 18.4 ± 2.1 | 39.5 ± 2.7 | 55.2 ± 3.3 | 111.4 ± 14.3 |
 | 50 μM | |||
UM-1 | - | - | - | 17.4 ± 2.3 |
UM-2 | 23.8 ± 1.9 | 56.3 ± 2.7 | 100.7 ± 2.2 | 172.9 ± 0.6 |
 | 75 μM | |||
UM-1 | - | - | - | 24.2 ± 3.3 |
UM-2 | 22.0 ± 0.5 | 57.6 ± 4.2 | 129.5 ± 1.6 | 234.1 ± 5.0 |
 | 100 μM | |||
UM-1 | - | - | - | 36.2 ± 5.6 |
UM-2 | 19.3 ± 1.3 | 61.7 ± 3.1 | 144.8 ± 7.9 | 263.7 ± 2.5 |
 | 200 μM | |||
UM-1 | - | - | - | 47.6 ± 4.6 |
UM-2 | 16.1 ± 2.1 | 60.4 ± 2.9 | 178.3 ± 9.2 | 398.2 ± 17.2 |