Figure 2

The ratio post- to pre-treatment iNOS protein expression (optical density). iNOS expression did not change significantly in any group and the change did not differ significantly between the groups: A: saline (150 mM NaCl) (n = 6), B: CGP 42112A at increasing infusion rates (0.01 μg kg^-1 min^-1, 0.1 μg kg^-1 min^-1,1.0 μg kg^-1 min^-1 iv) (n = 6), C: CGP 42112A (as in B) in the presence of PD123319 (0.3 mg kg^-1 iv bolus and 0.03 mg kg^-1h^-1 iv infusion administration initiated at baseline) (n = 6).