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Figure 2 | BMC Pharmacology

Figure 2

From: Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening.

Figure 2

DAMGO and morphine-stimulated [35S] GTPγS binding at hMOR and Ala348,353 hMOR. Increasing concentrations of DAMGO and morphine (10-10 to 10-4 M) were used to stimulate [35S] GTPγS binding. Panel A: DAMGO at hMOR (■) or at Ala348,353 hMOR (). Panel B: morphine at hMOR () or Ala348,353 hMOR (▲). Data are given as the mean ± S.E.M. from at least 3 independent experiments performed in triplicate.

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