Table 2 Muscle damage caused by injection of adenovirus in rats. The muscle lesions were assessed, as described in table 1, two days after the intramuscular injection of the adenoviral vector. The total muscle inflammation and damage scores range from 0–3 and 0–12 respectively. 4 animals per group. The CPK were measured 2 days after the vector injection. Values show the mean ± SD.
From: Pharmacogenetic heterogeneity of transgene expression in muscle and tumours
| Â | High dose (1010iu) | |
|---|---|---|
| Â | Brown Norway | Wag / Rij |
Total muscle inflammation | 1.2 ± 0.5 | 1.0 ± 0.8 |
Total muscle damage | 2.2 ± 0.5 | 2.4 ± 0.8 |
Total muscle proteins (mg/g tissue) | 85 ± 22 | 77 ± 33 |
CPK in plasma (IU) | 950 ± 205 | 1096 ± 173 |