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Table 2 Binding Profiles of Opioid ligands in HEK-μ cells

From: Activity of opioid ligands in cells expressing cloned mu opioid receptors

LIGAND

AFFINITY Ki (nM)

Cyclazocine

0.22 ± 0.02

DAMGO

2.65 ± 0.75

Morphine

2.2 ± 0.5

Naltrexone

0.74 ± 0.06

SKF 10047

1.15 ± 0.05

WIN 44,441

0.99 ± 0.31

Xorphanol

0.25 ± 0.01

  1. Competition binding assays were carried out in cell homogenates of HEK-μ cells as described under "Materials and Methods". Data represent mean ± SEM of Ki values from two or more independent experiments carried out in triplicate.
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BMC Pharmacology

ISSN: 1471-2210