Effect of clozapine i.t. or i.c.v. on contraction time, expulsion time and amplitude of the high frequency oscillations (HFO). Data from intravenous administration of clozapine  are presented for comparison. A) Contraction time was not affected by clozapine i.t. or i.c.v.; B) Expulsion time was decreased by both clozapine i.t. or i.c.v. However, 5 nmoles of clozapine i.t. resulted in a greater reduction in expulsion time than the same dose given i.c.v. Only the highest dose (50 nmoles) resulted in a decrease in the expulsion time when given i.c.v. C) The amplitude of the HFO was significantly reduced by 5 and 50 nmoles ofclozapie i.t. but only by 50 nmoles of clozapine i.c.v. The effect of 5 nmoles of clozapine i.t. was significantly different from the same dose given i.c.v. V= vehicle administration (saline) for i.t. or i.c.v. groups; (V) = vehicle administration for i.v. group. * = p < 0.05; ** = p < 0.01; # = p < 0.05 when compared to the effects of the same dose, different route.