Figure 5

Effect of clozapine i.t. or i.c.v. on contraction time, expulsion time and amplitude of the high frequency oscillations (HFO). Data from intravenous administration of clozapine [12] are presented for comparison. A) Contraction time was not affected by clozapine i.t. or i.c.v.; B) Expulsion time was decreased by both clozapine i.t. or i.c.v. However, 5 nmoles of clozapine i.t. resulted in a greater reduction in expulsion time than the same dose given i.c.v. Only the highest dose (50 nmoles) resulted in a decrease in the expulsion time when given i.c.v. C) The amplitude of the HFO was significantly reduced by 5 and 50 nmoles ofclozapie i.t. but only by 50 nmoles of clozapine i.c.v. The effect of 5 nmoles of clozapine i.t. was significantly different from the same dose given i.c.v. V= vehicle administration (saline) for i.t. or i.c.v. groups; (V) = vehicle administration for i.v. group. ^* = p < 0.05; ^** = p < 0.01; # = p < 0.05 when compared to the effects of the same dose, different route.