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Figure 6 | BMC Pharmacology

Figure 6

From: Activation of the peroxisome proliferator-activated receptor α protects against myocardial ischaemic injury and improves endothelial vasodilatation

Figure 6

Fenofibrate improves endothelial function. Acetylcholine-induced relaxation in mesenteric bed (A) and thoracic aorta (B). Results were expressed as a percent of the initial phenylephrine- or U46619-induced pre-contraction level. The values of contraction obtained with phenylephrine (10 μM) in mesenteric bed from control and fenofibrate-treated mice were 10.8 ± 1.1 mmHg (n = 9) and 11.44 ± 1.5 mmHg (n = 9), respectively. The values of contraction obtained with U46619 (30 nM) in aorta from control and fenofibrate-treated mice were 3.26 ± 0.2 mN/mm (n = 8) and 3.01 ± 0.2 mN/mm (n = 8) respectively. Data are the mean ± SEM of 8–9 experiments. * P < 0.05, ** P < 0.01. Representative Western-blot of endothelial NO-synthase (eNOS) protein expression in mesenteric bed (C) and thoracic aortic segments (D) from control (CON) and fenofibrate-treated (FF) mice. Positive control (C) is the eNOS from bovine endothelial cells. Similar results were obtained in three separate experiments.

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BMC Pharmacology

ISSN: 1471-2210