Effect of chronic 5-HT or vehicle infusion on A) mean arterial pressure (MAP), B) heart rate (HR), C) cardiac index (CI), D) stroke volume, and E) total peripheral resistance (TPRI). Data points are 1-hr group means +/− SEM. Number of animals per group is shown in parentheses. The vertical line denotes 5-HT or vehicle osmotic pump implant. C1 and C2 - control recordings. S1 – S7 days since initiation of 5-HT/vehicle infusion. * P < 0.05 vs. vehicle.