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Table 4 Oxygen consumption, Respiratory Quotient, and unbound plasma exposure in S-D rats administered CE-178253

From: Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) Receptor Antagonist

Dose (mg/kg, p.o.)

VO2, ave, 1-3 hr

( ± S-D)

Respiratory Quotient

(VCO2/VO2)

Unbound Plasma Concentration

(nM ± S-D )

Unbound plasma/rat brain

CB1 R Ki

Veh.

3 ± 5

0.85 ± 0.03

NA

NA

1

28 ± 7*

0.74 ± 0.02*

0.8 ± 0.2

1.8

3

39 ± 5*

0.75 ± 0.03*

3.8 ± 0.9

8.8

  1. *significantly different from veh. p < 0.05
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BMC Pharmacology

ISSN: 1471-2210