Figure 3

Inhibition of mitochondrial ROS generation by pramipexole (PPX) enantiomers. Cells were exposed to different concentrations, as indicated in the bottom, of S(-) PPX (upper panel) and R(+) PPX (lower panel) for 1 h before being exposed to laser. Mitochondrial ROS generation was evaluated as in figure 2. Data represent means ± SEM of at least three different experiments and are from three separate cell preparations. *, p < 0.05 and **, p < 0.001 vs the corresponding control values (black bars).