Figure 3

Histopathological changes in liver after administration of sunitinib (H&E staining). A: Photomicrograph (200x) of liver section after administration of 25 mg/kg sunitinib showing vascular congestion (arrows) in the central veins and red blood cells pooling in the sinusoids. B: Liver section (400x) after administration of sunitinib 25 mg/kg. Notice a microabscess (circle) involving a few hepatocytes with inflammatory cells and necrotic debris. Hepatocytes undergoing cytoplasmic condensation and regeneration are also observed (arrow). C: Photomicrograph (100x) from the sunitinib 80 mg/kg group showing vascular congestion involving the central veins amidst hepatocytes surrounded by dilated sinusoids. D: Photomicrograph (400x) from the sunitinib 100 mg/kg group. Notice the hepatocytes in various stages of cytoplasmic condensation, suggesting early stages of cell injury.