Figure 13

Photomicrographs of the histopathology of the spleen (H&E staining). Histopathological changes were observed only at the highest dose of sunitinib (140 mg/kg) coadministered with paracetamol. A: photomicrograph (100x) from the control saline group showing normal morphology of the spleen including the red and white pulp areas. B: photomicrograph (200x) after coadministration of sunitinib 140 mg/kg and paracetamol showing areas of cellularity admixed with mild congestion.