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Figure 2 | BMC Pharmacology

Figure 2

From: Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling

Figure 2

Direct interaction between SalB and MMP-9 catalytic domain. (A) Representative structural domains of MMP-9. (B) Amino acid sequence of recombinant MMP-9 CD. (C) MMP-9 CD displayed significant collagenase activity detected by zymography assay. (D) Direct binding of SalB to MMP-9 by BIAcore analysis. The binding affinity of SalB with MMP-9 CD was reflected by response unit (RU) values. Immobilization of MMP-9 CD on the Biacore biosensor chip resulted in a resonance signal of 8000 RUs. The kinetic measurements were performed in triplicate using a set of serial dilutions as shown.

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BMC Pharmacology

ISSN: 1471-2210