Table 1 Time elapsed (sec.) for nociceptive response in Hot Plate Test in mice related to the time of experiment.

Control

7

3.4 ± 1.2

3.4 ± 1.5

NS

5.2 ± 0.92

NS

7.04 ± 0.75

NS

6.0 ± 0.95

NS

Morphine 20 mg.kg ^-1

6

2.07 ± 0.65

6.9 ± 0.76

203%**

8.15 ± 1.52

163.5%*

13.35 ± 4.05

189.6%**

6.8 ± 2.11

NS

Naloxone 1 mg.kg¹/control

6

3.0 ± 0.39

4.72 ± 0.77

NS

5.3 ± 0.7

NS

6.25 ± 1.23

NS

6.65 ± 0.9

NS

Naloxone 1 mg.kg¹/Morphine20 mg.kg¹

8

3.6 ± 1.12

4.81 ± 1.42

NS

7.07 ± 2.23

NS

5.2 ± 1.53

NS

6.0 ± 1.27

NS

C2 100 mg.kg ^-1

8

3.5 ± 1.0

4.88 ± 2.21

NS

12.35 ± 1.24

237.5%**

11.5 ± 2.77

163.4%**

7.38 ± 0.76

NS

Naloxone1 mg.kg¹/C2 100 mg.kg¹

7

3.4 ± 1.2

4.21 ± 1.8

NS

11.5 ± 2.11

221.2%**

9.41 ± 2.69

NS

6.65 ± 2.8

NS

C1 100 mg.kg ^-1

8

3.1 ± 1.2

6.16 ± 2.0

179%**

10.66 ± 2.13

205%**

8.98 ± 1.48

NS

9.2 ± 2.4

153.3%**

Naloxone1 mg.kg¹/C1 100 mg.kg¹

8

3.5 ± 1.3

5.0 ± 1.68

NS

13.42 ± 2.24

258%**

12.06 ± 2.27

171.3%**

6.7 ± 2.12

NS