Figure 4

Interaction of receptorphin with somatostatin binding sites. A: Effect of receptorphin on the proliferation of LNCaP cells, not-presenting opioid binding sites [38]. Conditions of cell growth were similar with those presented in the legend of Figure 2, with the exception that cells were assayed at day 6, as the doubling time of LNCaP cells is longer (3.02d). Mean ± SEM of three experiments in triplicate. B. Competition of receptorphin for somatostatin binding. Displacement of radiolabelled [¹²⁵I]Tyr¹¹Somatostatin14 by varying concentrations of receptorphin. See text for details of binding.