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Figure 7 | BMC Pharmacology

Figure 7

From: Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia

Figure 7

The time-course of MMP-2 and MMP-9 expression in neonatal rat brain microglia cultured in the presence of LPS or Domoic acid. MMP-2 and MMP-9 were determined as described in Materials and Methods. (A) SDS-PAGE zymography (B) bar-graph depicting the quantitated results. Neonatal rat brain microglia (2.8–5 × 106 cells/culture dish) were treated with LPS [10 ng/ml] or Domoic acid [1 mM] for 1–6 hours. Data (inverse o.d. units) are expressed as mean ± SE of values obtained from 3 independent experiments. **p < 0.01 vs. vehicle control.

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BMC Pharmacology

ISSN: 1471-2210