Articles
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Citation: BMC Pharmacology 2005 5(Suppl 1):P61
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NO-sensitive guanylyl cyclase: Identification and purification of the dimerization domain
Citation: BMC Pharmacology 2005 5(Suppl 1):P57 -
NMDA treatment stabilizes the mRNA encoding for α2 subunit of the NO-sensitive guanylyl cyclase by decreasing AUF1 protein level through a NO-cGMP-dependent mechanism
Citation: BMC Pharmacology 2005 5(Suppl 1):P55 -
The elusive β2 subunit of sGC
Citation: BMC Pharmacology 2005 5(Suppl 1):P53 -
Activation of NF-κB by nitric oxide/cGMP in human blood CD14+ cells
Citation: BMC Pharmacology 2005 5(Suppl 1):P51 -
Residues stabilizing the heme moiety of the NO sensor soluble guanylate cyclase
Citation: BMC Pharmacology 2005 5(Suppl 1):P49 -
NO-sensitive guanylyl cyclase: binding and dissociation of nitric oxide
Citation: BMC Pharmacology 2005 5(Suppl 1):P47 -
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension
Citation: BMC Pharmacology 2005 5(Suppl 1):P45 -
Role of nitric oxide and cyclic GMP in proliferation and differentiation of murine and human embryonic stem cells
Citation: BMC Pharmacology 2005 5(Suppl 1):S38 -
Lessons from soluble guanylate cyclase alpha1 knockouts
Citation: BMC Pharmacology 2005 5(Suppl 1):S36 -
Effects of stimulating the cGMP pathway on spontaneous activity in pacemaker cells isolated from the rabbit urethra
Citation: BMC Pharmacology 2005 5(Suppl 1):S34 -
Role of soluble guanylate cyclase in progressive renal fibrosis
Citation: BMC Pharmacology 2005 5(Suppl 1):S32 -
Soluble guanylate cyclase stimulator attenuates acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs
Citation: BMC Pharmacology 2005 5(Suppl 1):S28 -
Increased tissue expression and activity of cGMP-dependent protein kinase I in ANP-receptor (GC-A) – deficient mice
Citation: BMC Pharmacology 2005 5(Suppl 1):P25 -
Nerve-induced release of nitric oxide from the rabbit corpus cavernosum is modulated by cyclic GMP
Citation: BMC Pharmacology 2005 5(Suppl 1):P22 -
Binding of [3H]BAY 58-2667 to purified bovine lung soluble guanylate cyclase by scintillation proximity assay
Citation: BMC Pharmacology 2005 5(Suppl 1):P20 -
Role of activators of ferric sGC in cardiovascular disease
Citation: BMC Pharmacology 2005 5(Suppl 1):S19 -
Gene inactivation of the β1 subunit of NO-sensitive guanylyl cyclase in mice
Citation: BMC Pharmacology 2005 5(Suppl 1):P18 -
Activation of soluble guanylate cyclase reverses pulmonary vascular remodeling induced by hypoxia in mice
Citation: BMC Pharmacology 2005 5(Suppl 1):P16 -
NO-induced motility effects in distal colon of sGCα1 knockout mice
Citation: BMC Pharmacology 2005 5(Suppl 1):P14 -
NO-cGMP signaling in the guinea pig bladder
Citation: BMC Pharmacology 2005 5(Suppl 1):P12 -
Regulation of spontaneous activity in rabbit corpus cavernosum myocytes by nitric oxide
Citation: BMC Pharmacology 2005 5(Suppl 1):P10 -
Regulation of cyclic nucleotide hydrolysis by cGMP
Citation: BMC Pharmacology 2005 5(Suppl 1):S9 -
Atypical soluble guanylyl cyclases in Drosophila as neutral oxygen sensors and their involvement in gestation
Citation: BMC Pharmacology 2005 5(Suppl 1):S7 -
Selective inhibitors of cGMP phosphodiesterases as procognitive agents
Citation: BMC Pharmacology 2005 5(Suppl 1):S5 -
In vivo modulation of vasodilator stimulated phosphoprotein functions by phosphorylation
Citation: BMC Pharmacology 2005 5(Suppl 1):P4 -
Resonance raman investigation of effects of YC-1 and GTP on structure of CO-bound heme of soluble guanylate cyclase
Citation: BMC Pharmacology 2005 5(Suppl 1):S3 -
IRAG is involved in NO/cGMP-mediated inhibition of platelet function
Citation: BMC Pharmacology 2005 5(Suppl 1):P2 -
Molecular steps in soluble guanylate cyclase activation
Citation: BMC Pharmacology 2005 5(Suppl 1):S1 -
Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T
Cardiac hypertrophy is a major risk factor for morbidity and mortality in a number of cardiovascular diseases. Consequently, the signaling pathways that inhibit cardiac hypertrophy are currently receiving much...
Citation: BMC Pharmacology 2005 5:10 -
Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats
In this study, we tested the hypothesis that 17β-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increa...
Citation: BMC Pharmacology 2005 5:9 -
Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport
The first generation antihistamines, such as diphenhydramine, are fairly potent muscarinic antagonists in addition to being H1 selective antihistamines. The antimuscarinic action is often not desirable since i...
Citation: BMC Pharmacology 2005 5:8 -
Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity
The nucleoside analogue arabinosylcytosine (araC) has been used for many years in the treatment of acute leukemia. Evidence in the literature suggests that araC may inhibit the growth of human colon carcinoma ...
Citation: BMC Pharmacology 2005 5:7 -
Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines
Thromboxane B2 (TXB2) and superoxide anion (O2-) are neuroinflammatory mediators that appear to be involved in the pathogenesis of several neurodegenerative diseases. Because activated-microglia are the main sour...
Citation: BMC Pharmacology 2005 5:6 -
Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs – method development and application to magnesium in sheep
There have been few reports of pharmacokinetic models that have been linked to models of the cardiovascular system. Such models could predict the cardiovascular effects of a drug under a variety of circumstanc...
Citation: BMC Pharmacology 2005 5:5 -
Application of population pharmacokinetics to cladribine
The nucleoside analog cladribine is used for the treatment of a variety of indolent B- and T-cell lymphoid malignancies. The primary aim of the study was to evaluate the population distribution of pharmacokine...
Citation: BMC Pharmacology 2005 5:4 -
Cross-talk between phosphatidic acid and ceramide during ethanol-induced apoptosis in astrocytes
Ethanol inhibits proliferation in astrocytes, an effect that was recently linked to the suppression of phosphatidic acid (PA) formation by phospholipase D (PLD). The present study investigates ethanol's effect...
Citation: BMC Pharmacology 2005 5:3 -
Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney
CCl4 is a well-established hepatotoxin inducing liver injury by producing free radicals. Exposure to CCl4 also induces acute and chronic renal injuries. The present study was designed to establish the protective ...
Citation: BMC Pharmacology 2005 5:2 -
Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram
Before therapeutic effect is obtained after treatment with antidepressant drugs, like serotonin selective reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAO-Is)...
Citation: BMC Pharmacology 2005 5:1 -
Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
Probimane (Pro), an anti-cancer agent originating in China, was derived from razoxane (ICRF-159, Raz), a drug created in Britain, specifically targeting at cancer metastasis and as a cardioprotectant of anthro...
Citation: BMC Pharmacology 2004 4:32 -
Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells
Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA repre...
Citation: BMC Pharmacology 2004 4:31 -
Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats
Reserpine, an alkaloid from Rauwolfia serpentina was widely used for its antihypertensive action in the past. In later years, its use has been reduced because of precipitation of depression and extra pyramidal sy...
Citation: BMC Pharmacology 2004 4:30 -
Effect of dietary palm olein oil on oxidative stress associated with ischemic-reperfusion injury in isolated rat heart
Palm olein oil (PO), obtained from refining of palm oil is rich in monounsaturated fatty acid and antioxidant vitamins and is widely used as oil in diet in many parts of the world including India. Palm oil has...
Citation: BMC Pharmacology 2004 4:29 -
Long-term age-dependent behavioral changes following a single episode of fetal N-methyl-D-Aspartate (NMDA) receptor blockade
Administration of the N-methyl-D-aspartate (NMDA) antagonist ketamine during the perinatal period can produce a variety of behavioral and neuroanatomical changes. Our laboratory has reported reliable changes i...
Citation: BMC Pharmacology 2004 4:28 -
Weight loss dynamics during combined fluoxetine and olanzapine treatment
Fluoxetine and olanzapine combination therapy is rapidly becoming an effective strategy for managing symptoms of treatment-resistant depression. Determining drug-drug interactions, drug metabolism and pharmaco...
Citation: BMC Pharmacology 2004 4:27 -
Peroxynitrite-mediated inactivation of heme oxygenases
Endogenous nitric oxide (NO) and carbon monoxide (CO) are generated by nitric oxide synthase and heme oxygenase, respectively. Like NO, CO has been accepted as an important cellular signaling molecule in biolo...
Citation: BMC Pharmacology 2004 4:26 -
Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats
The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats.
Citation: BMC Pharmacology 2004 4:25 -
Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration
The activation of GABAB receptors in the ventral tegmental area (VTA) has been suggested to attenuate the rewarding properties of psychostimulants, including nicotine. However, the neurochemical mechanism that un...
Citation: BMC Pharmacology 2004 4:24 -
Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats
PPARγ agonists ameliorate insulin resistance and dyslipidemia in type 2 diabetic patients. Adiponectin possesses insulin sensitizing properties, and predicts insulin sensitivity of both glucose and lipid metab...
Citation: BMC Pharmacology 2004 4:23 -
In vitro pharmacokinetics of anti-psoriatic fumaric acid esters
Psoriasis is a chronic inflammatory skin disease that can be successfully treated with a mixture of fumaric acid esters (FAE) formulated as enteric-coated tablets for oral use. These tablets consist of dimethy...
Citation: BMC Pharmacology 2004 4:22