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  1. We use silkworms to evaluate therapeutic effects of drug candidates. Our previous reports have revealed that there are common mechanisms of pharmacokinetics of chemicals in silkworms and mammals. In this repor...

    Authors: Yukihiro Asami, Ryo Horie, Hiroshi Hamamoto and Kazuhisa Sekimizu

    Citation: BMC Pharmacology 2010 10:7

    Content type: Methodology article

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  2. It is long known within the mathematical literature that the coefficient of determination R2 is an inadequate measure for the goodness of fit in nonlinear models. Nevertheless, it is still frequently used within ...

    Authors: Andrej-Nikolai Spiess and Natalie Neumeyer

    Citation: BMC Pharmacology 2010 10:6

    Content type: Research article

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  3. Long-term amphetamine and methamphetamine dependence has been linked to cerebral blood perfusion, metabolic, and white matter abnormalities. Several studies have linked methamphetamine abuse to cortical grey m...

    Authors: Glenn Lawyer, Petr S Bjerkan, Anders Hammarberg, Nitya Jayaram-Lindström, Johan Franck and Ingrid Agartz

    Citation: BMC Pharmacology 2010 10:5

    Content type: Research article

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  4. Benzylisoquinoline is the structural backbone of many alkaloids with a wide variety of structures including papaverine, noscapine, codeine, morphine, apomorphine, berberine, protopine and tubocurarine. Many be...

    Authors: Deepak Singla, Arun Sharma, Jasjit Kaur, Bharat Panwar and Gajendra PS Raghava

    Citation: BMC Pharmacology 2010 10:4

    Content type: Database

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  5. The traditional emphasis on developing high specificity pharmaceuticals ("magic bullets") for the treatment of Neurological and Psychiatric disorders is being challenged by emerging pathophysiology concepts th...

    Authors: Matt T Bianchi and Emmanuel J Botzolakis

    Citation: BMC Pharmacology 2010 10:3

    Content type: Hypothesis

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  6. Pramipexole exists as two isomers. The S(-) enantiomer is a potent D3/D2 receptor agonist and is extensively used in the management of PD. In contrast, the R(+) enantiomer is virtually devoid of any of the DA ago...

    Authors: Giulia Ferrari-Toninelli, Giuseppina Maccarinelli, Daniela Uberti, Erich Buerger and Maurizio Memo

    Citation: BMC Pharmacology 2010 10:2

    Content type: Research article

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  7. Pterodon pubescens Benth seeds are commercially available in the Brazilian medicinal plant street market. The crude alcoholic extracts of this plant are used in folk medicine as anti-inflammatory, analgesic, and ...

    Authors: Humberto M Spindola, Leila Servat, Carina Denny, Rodney AF Rodrigues, Marcos N Eberlin, Elaine Cabral, Ilza MO Sousa, Jorge Y Tamashiro, João E Carvalho and Mary A Foglio

    Citation: BMC Pharmacology 2010 10:1

    Content type: Research article

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  8. Many neuromuscular blockers act as negative allosteric modulators of muscarinic acetylcholine receptors by decreasing affinity and potency of acetylcholine. The neuromuscular blocker rapacuronium has been show...

    Authors: Jan Jakubík, Alena Randáková, Esam E El-Fakahany and Vladimír Doležal

    Citation: BMC Pharmacology 2009 9:15

    Content type: Research article

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  9. Activation of muscarinic M1 receptors is mediated via interaction of orthosteric agonists with the acetylcholine binding site or via interaction of allosteric agonists with different site(s) on the receptor. The ...

    Authors: Christopher N Davis, Stefania Risso Bradley, Hans H Schiffer, Mikael Friberg, Kristian Koch, Bo-Ragnar Tolf, Douglas W Bonhaus and Jelveh Lameh

    Citation: BMC Pharmacology 2009 9:14

    Content type: Research article

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  10. Authors: Anupam Sah, Stefano Gaburro, Claudia Schmuckermair, Simone B Sartori, Markus Hauschild, Ludwig Czibere, Regina Irschick, Lars Klimaschewski, Rainer Landgraf and Nicolas Singewald

    Citation: BMC Pharmacology 2009 9(Suppl 2):A19

    Content type: Meeting abstract

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    This article is part of a Supplement: Volume 9 Supplement 2