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Activation of soluble guanylyl cyclase (sGC) by the NO/heme-independent activator HMR1766 in cells

Authors: Zongmin Zhou, Anastasia Kotanidou, Charis Roussos and Andreas Papapetropoulos

Citation: BMC Pharmacology 2007 7(Suppl 1):P69

Content type: Poster presentation Published on: 25 July 2007

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Exercise training effects on vascular reactivity and metabolic parameters of high caloric-fed Wistar rats

Authors: Angelina Zanesco, Camila de Moraes, AP Davel, LV Rossoni, Gilberto de Nucci and Edson Antunes

Citation: BMC Pharmacology 2007 7(Suppl 1):P67

Content type: Poster presentation Published on: 25 July 2007

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Hyper-contractility and impaired cGMP signaling in the BK_Ca channel deletion model of erectile dysfunction

Authors: Matthias E Werner, Andrea L Meredith, Richard W Aldrich and Mark T Nelson

Citation: BMC Pharmacology 2007 7(Suppl 1):P65

Content type: Poster presentation Published on: 25 July 2007

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Effects of BAY 41–2272 on smooth muscle tone, soluble guanylyl cyclase activity and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal and endothelial NOS null mice

Authors: Cleber E Teixeira, Fernanda BM Priviero and RClinton Webb

Citation: BMC Pharmacology 2007 7(Suppl 1):P58

Content type: Poster presentation Published on: 25 July 2007

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ANP changes microvascular endothelial barrier function in vivo

Authors: Barbara Schreier, Birgit Gaßner, Katharina Völker, Stepan Gambaryan and Michaela Kuhn

Citation: BMC Pharmacology 2007 7(Suppl 1):P53

Content type: Poster presentation Published on: 25 July 2007

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Increased ventilatory lung stretch alters the effect of soluble guanylyl cyclase-derived cGMP on endothelial barrier function in isolated mouse lungs

Authors: EP Schmidt, AJ Gonzales, LE Servinsky, JM Dodd-o and David B Pearse

Citation: BMC Pharmacology 2007 7(Suppl 1):P51

Content type: Poster presentation Published on: 25 July 2007

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Desensitization of soluble guanylyl cyclase, the NO-receptor, by S-nitrosylation

Authors: Nazish Sayed, Padmamalini Baskaran, Focco van den Akker and Annie Beuve

Citation: BMC Pharmacology 2007 7(Suppl 1):P50

Content type: Poster presentation Published on: 25 July 2007

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Regulation of cGMP by phosphodiesterases (PDEs) in the central nervous system

Authors: Frank S Menniti, Robin J Kleiman and Christopher J Schmidt

Citation: BMC Pharmacology 2007 7(Suppl 1):S48

Content type: Oral presentation Published on: 25 July 2007

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cGMP signaling and bifurcation of sensory axons at the dorsal root entry zone of the spinal cord

Authors: Agne Stonkute, Hannes Schmidt, Rene Jüttner, Susanne Schäffer, Jens Buttgereit, Robert Feil, Franz Hofmann and Fritz G Rathjen

Citation: BMC Pharmacology 2007 7(Suppl 1):S47

Content type: Oral presentation Published on: 25 July 2007

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cGMP-dependent kinase I supports formation of associative fear memory and long-term potentiation in the lateral amygdala

Authors: Cindy Paul, Pascal Weinmeister, Robert Feil, Franz Hofmann and Thomas Kleppisch

Citation: BMC Pharmacology 2007 7(Suppl 1):P46

Content type: Poster presentation Published on: 25 July 2007

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NPR-A gene deletion reverses vascular dysfunction associated with sepsis

Authors: Catherine M Panayiotou and Adrian J Hobbs

Citation: BMC Pharmacology 2007 7(Suppl 1):P44

Content type: Poster presentation Published on: 25 July 2007

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The formation of a Ca²⁺-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform

Authors: Michael Nesheim, John Samis, John Walker, Timothy Fischer, Liliana Tejidor, Greg Jones, Wim Houdijk, Alan Giles, Lev Becker, Marlys Koschinsky, Richard Wenstone, Colin Downey and Cheng Hock Toh

Citation: BMC Pharmacology 2007 7(Suppl 1):P42

Content type: Poster presentation Published on: 25 July 2007

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Supersensitivity of muscarinic receptors in rat isolated detrusor smooth muscle (DSM) after chronic nitric oxide inhibition

Authors: Fabiola Mónica, Gilberto de Nucci, Alice Bricola, Angelina Zanesco, Catarina Porto, Fernando Abdalla, Leandro Freitas, Maria Aparecida Teixeira and Edson Antunes

Citation: BMC Pharmacology 2007 7(Suppl 1):P41

Content type: Poster presentation Published on: 25 July 2007

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Fresh look on old substances – new class of NO-independent regulators of soluble guanylyl cyclase activity and function

Authors: Emil Martin, Elena Bogatenkova, Ka Bian and Marie-Francoise Doursout

Citation: BMC Pharmacology 2007 7(Suppl 1):P40

Content type: Poster presentation Published on: 25 July 2007

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Pharmacokinetic and pharmacodynamic study of a novel chimeric natriuretic peptide, CD-NP, in the normal dog

Authors: Candace YW Lee, Guido Boerrigter, Gail J Harty and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P38

Content type: Poster presentation Published on: 25 July 2007

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PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system: role in pathogenesis of migraine?

Authors: Lars S Kruse, Morten Møller, Maiken Tibæk, Steen Gammeltoft, Jes Olesen and Christina Kruuse

Citation: BMC Pharmacology 2007 7(Suppl 1):P36

Content type: Poster presentation Published on: 25 July 2007

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Hsp90 and sGC-mediated vasorelaxation

Authors: John D Catravas

Citation: BMC Pharmacology 2007 7(Suppl 1):S35

Content type: Oral presentation Published on: 25 July 2007

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cGMP-Protein kinase G signaling pathway is involved in stimulation of Leydig cell steroidogenesis

Authors: Tatjana Kostic, Marija Janjic, Natasa Stojkov, Stanko Stojilkovic and Silvana Andric

Citation: BMC Pharmacology 2007 7(Suppl 1):P34

Content type: Poster presentation Published on: 25 July 2007

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Influence of heme metabolism and redox regulation of sGC in the control of vascular function

Authors: Michael S Wolin, Sachin A Gupte, Mansoor Ahmad and Christopher J Mingone

Citation: BMC Pharmacology 2007 7(Suppl 1):S33

Content type: Oral presentation Published on: 25 July 2007

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Vascular smooth muscle PDE5 is much more sensitive to N-alkylated zaprinast than platelet PDE5

Authors: Jacques F Kameni-Tcheudji, Thérèse Keravis, Alain Le Bec, Luc Lebeau, Jean-Marie Strub, Alain van Dorsselaer and Claire Lugnier

Citation: BMC Pharmacology 2007 7(Suppl 1):P32

Content type: Poster presentation Published on: 25 July 2007

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Melanocytes: interface of cell biology and pathobiology with a focus on nitric oxide and cGMP signaling

Authors: Krassimira Ivanova, Pranab Kumar Das and Rupert Gerzer

Citation: BMC Pharmacology 2007 7(Suppl 1):S31

Content type: Oral presentation Published on: 25 July 2007

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Integrin receptor subtype antagonism augments BNP-mediated cGMP generation in cultured human cardiac fibroblasts: evidence for particulate guanylate cyclase receptor and integrin receptor cross-talk

Authors: Brenda K Huntley and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P30

Content type: Poster presentation Published on: 25 July 2007

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Phosphorylation of cAMP hydrolyzing PDE (PDE3A) by cGMP-dependent protein kinase (PKG) in human platelets

Authors: Sergei D Rybalkin, Irina G Rybalkina and Joseph A Beavo

Citation: BMC Pharmacology 2007 7(Suppl 1):S29

Content type: Oral presentation Published on: 25 July 2007

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Cardiovascular effects of the soluble guanylyl cyclase activator BAY 58–2667 in anesthetized dogs

Authors: Michael Hoffmann and Uwe Thuss

Citation: BMC Pharmacology 2007 7(Suppl 1):P28

Content type: Poster presentation Published on: 25 July 2007

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Molecular steps in sGC activation

Authors: Elizabeth M Boon, Stephen PL Cary, Shirley H Huang, Jonathan A Winger, Emily R Derbyshire, Mark S Price, William K Erbil and Michael A Marletta

Citation: BMC Pharmacology 2007 7(Suppl 1):S27

Content type: Oral presentation Published on: 25 July 2007

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Characterization of an epitope-tagged guanylyl cyclase-A receptor

Authors: Michael Hartmann, Juliane Schröter, Viacheslav O Nikolaev, Albert Sickmann, Ruey-Bing Yang and Michaela Kuhn

Citation: BMC Pharmacology 2007 7(Suppl 1):P26

Content type: Poster presentation Published on: 25 July 2007

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Specificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities

Authors: Joseph A Beavo, Johannes L Bos, Elke Butt, Stein O Doskeland, Hans-Gottfried Genieser, Thomas R Hinds, Heiko Poppe, Holger Rehmann, Sergei D Rybalkin, Frank Schwede and Xiao-Bo Tang

Citation: BMC Pharmacology 2007 7(Suppl 1):S25

Content type: Oral presentation Published on: 25 July 2007

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cGMP compartments in cardiac myocytes

Authors: Rodolphe Fischmeister and Liliana Castro

Citation: BMC Pharmacology 2007 7(Suppl 1):S23

Content type: Oral presentation Published on: 25 July 2007

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Rapid monitoring of intracellular cGMP

Authors: Viacheslav O Nikolaev and Martin J Lohse

Citation: BMC Pharmacology 2007 7(Suppl 1):S21

Content type: Oral presentation Published on: 25 July 2007

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BAY 63–2521, an oral soluble guanylate cyclase stimulator, has a favourable safety profile and decreases peripheral vascular resistance in healthy male volunteers

Authors: Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann and Georg Wensing

Citation: BMC Pharmacology 2007 7(Suppl 1):P20

Content type: Poster presentation Published on: 25 July 2007

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Effect of new sildenafil analogues in the rabbit isolated aorta

Authors: Haroldo A Flores Toque, Fernanda BM Priviero, Cleber E Teixeira, Edson Antunes and Gilberto de Nucci

Citation: BMC Pharmacology 2007 7(Suppl 1):P19

Content type: Poster presentation Published on: 25 July 2007

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New mouse models for the analysis of cGMP signalling

Authors: Robert Feil, Susanne Feil, Paul Franken, Yann Emmenegger, Mehdi Tafti, Karin Weindl, Sabine M Hölter, Wolfgang Wurst, Sonja Langmesser, Urs Albrecht, Michael Föller, Florian Lang, Silke Weber and Franz Hofmann

Citation: BMC Pharmacology 2007 7(Suppl 1):S19

Content type: Oral presentation Published on: 25 July 2007

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Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients

Authors: Vicente Felipo, Blanca Piedrafita, Amparo Urios, Miguel A Serra, A del Olmo, José M Rodrigo and Carmina Montoliu

Citation: BMC Pharmacology 2007 7(Suppl 1):P18

Content type: Poster presentation Published on: 25 July 2007

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Guanylyl cyclase-A mediated endothelial actions of natriuretic peptides are critically involved in postischemic reperfusion

Authors: Michaela Kuhn, Kristine Schwarz, Katharina Völker, Birgit Gaßner, Stepan Gambaryan, Hideo A Baba and Martin van Eickels

Citation: BMC Pharmacology 2007 7(Suppl 1):S17

Content type: Oral presentation Published on: 25 July 2007

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Chronic inhibition of cyclic GMP phosphodiesterase 5A may promote pressure overload-induced chamber dilatation in mice

Authors: Elisabeth Eder, Martin van Eickels, Stefan Frantz, Katharina Völker, Hideo A Baba and Michaela Kuhn

Citation: BMC Pharmacology 2007 7(Suppl 1):P17

Content type: Poster presentation Published on: 25 July 2007

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Analysis of mice with genetic modifications of PKG I

Authors: Franz Hofmann, Robert Lukowski, Dominik Bernhard, Pascal Weinmeister, Silke Weber, Susanne Feil, Jens Schlossmann, Jörg W Wegener and Robert Feil

Citation: BMC Pharmacology 2007 7(Suppl 1):S15

Content type: Oral presentation Published on: 25 July 2007

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Pharmacological characterization of the novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum

Authors: Gilberto De Nucci, Raquel Lorenzetti, Cristina E Okuyama, Juliana S Baracat, José L Donato, Edson Antunes and Cleber E Teixeira

Citation: BMC Pharmacology 2007 7(Suppl 1):P13

Content type: Poster presentation Published on: 25 July 2007

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Run training ameliorates the established erectile dysfunction in rats under long-term nitric oxide (NO) blockade

Authors: Mário A Claudino, Juliana S Baracat, Enilton A Camargo, Fernanda BM Priviero, Cleber E Teixeira, Gilberto de Nucci, Angelina Zanesco and Edson Antunes

Citation: BMC Pharmacology 2007 7(Suppl 1):P11

Content type: Poster presentation Published on: 25 July 2007

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The emerging role of PDE5 inhibition in heart failure

Authors: Gregory D Lewis, Jordan Shin, David M Systrom, Kenneth D Bloch and Marc J Semigran

Citation: BMC Pharmacology 2007 7(Suppl 1):S10

Content type: Oral presentation Published on: 25 July 2007

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BAY 58–2667, a soluble guanylate cyclase activator, improves cardiopulmonary haemodynamics in acute decompensated heart failure and has a favourable safety profile

Authors: Harald Lapp, Veselin Mitrovic, Norbert Franz, Hubertus Heuer, Michael Buerke, Judith Wolfertz, Wolfgang Mück, Sigrun Unger, Georg Wensing and Reiner Frey

Citation: BMC Pharmacology 2007 7(Suppl 1):S9

Content type: Oral presentation Published on: 25 July 2007

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Targeting heme-oxidized soluble guanylate cyclase with BAY 58-2667 in experimental heart failure

Authors: Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Harald Lapp, Johannes-Peter Stasch and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P9

Content type: Poster presentation Published on: 25 July 2007

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BAY 63–2521, an oral soluble guanylate cyclase stimulator, has a favourable safety profile, improves cardiopulmonary haemodynamics and has therapeutic potential in pulmonary hypertension

Authors: Hossein Ardeschir Ghofrani, Gerrit Weimann, Reiner Frey, Robert Voswinckel, Melanie Thamm, Desire Bölkow, Norbert Weissmann, Wolfgang Mück, Sigrun Unger, Georg Wensing, Ralph Theo Schermuly and Friedrich Grimminger

Citation: BMC Pharmacology 2007 7(Suppl 1):S8

Content type: Oral presentation Published on: 25 July 2007

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Relaxation of vascular smooth muscle by the cGMP-kinase substrate IRAG

Authors: Dominik Bernhard, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology 2007 7(Suppl 1):P8

Content type: Poster presentation Published on: 25 July 2007

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Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension

Authors: Adrian J Hobbs

Citation: BMC Pharmacology 2007 7(Suppl 1):S7

Content type: Oral presentation Published on: 25 July 2007

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Selective activation of hippocampal guanylyl cyclase by a novel NO mimetic nitrate ester

Authors: Brian Bennett, James Reynolds and Greg Thatcher

Citation: BMC Pharmacology 2007 7(Suppl 1):P6

Content type: Poster presentation Published on: 25 July 2007

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Relaxant effect of BAY 41–2272 in the rabbit isolated detrusor smooth muscle (DSM): involvement of cGMP-independent mechanisms

Authors: Fernando R Báu, Cleber E Teixeira, Gilberto De Nucci and Edson Antunes

Citation: BMC Pharmacology 2007 7(Suppl 1):P4

Content type: Poster presentation Published on: 25 July 2007

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Role of the sGC activator ataciguat sodium (HMR1766) in cardiovascular disease

Authors: Martin van Eickels, Sven Wassmann, Andreas Schäfer, Johann Bauersachs, Hartmut Strobel and Hartmut Rütten

Citation: BMC Pharmacology 2007 7(Suppl 1):S4

Content type: Oral presentation Published on: 25 July 2007

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Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO

The rational design of peptide-based specific inhibitors of the caspase family members using their X-ray crystallographies is an important strategy for chemical knockdown to define the critical role of each en...

Authors: Atsushi Yoshimori, Junichi Sakai, Satoshi Sunaga, Takanobu Kobayashi, Satoshi Takahashi, Naoyuki Okita, Ryoko Takasawa and Sei-ichi Tanuma

Citation: BMC Pharmacology 2007 7:8

Content type: Research article Published on: 27 June 2007
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Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa

The nasal tissue uptake and metabolism of ciclesonide, a new-generation corticosteroid under investigation for treatment of allergic rhinitis, to its active metabolite, desisobutyryl-ciclesonide (des-CIC), was...

Authors: Hideyuki Sato, Ruediger Nave, Takashi Nonaka, Nishibe Yoshihisa, Nagano Atsuhiro, Tsutomu Mochizuki, Shigehiro Takahama, Shiro Kondo and Mark Wingertzahn

Citation: BMC Pharmacology 2007 7:7

Content type: Research article Published on: 6 June 2007
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Clofibrate treatment in pigs: Effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents

In rodents treatment with fibrates causes hepatocarcinogenesis, probably as a result of oxidative stress and an impaired balance between apoptosis and cell proliferation in the liver. There is some debate whet...

Authors: Sebastian Luci, Beatrice Giemsa, Gerd Hause, Holger Kluge and Klaus Eder

Citation: BMC Pharmacology 2007 7:6

Content type: Research article Published on: 16 April 2007
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