Volume 9 Supplement 1

4th International Conference of cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

Regensburg, Germany19-21 June 2009

Page 2 of 3

cGKI signaling in cardiac hypertrophy

Authors: Robert Lukowski and Franz Hofmann

Citation: BMC Pharmacology 2009 9(Suppl 1):S26

Content type: Oral presentation Published on: 11 August 2009
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Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation

Authors: Linda Sarah Hoffmann, Peter Michael Schmidt, Yvonne Keim, Stefan Schaefer, Harald Schmidt and Johannes-Peter Stasch

Citation: BMC Pharmacology 2009 9(Suppl 1):P26

Content type: Poster presentation Published on: 11 August 2009
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A molecular view of the regulation of sGC activity

Authors: Michael A Marletta, Emily R Derbyshire, W Kaya Erbil, Nathaniel B Fernhoff, John Kuriyan, Charles Olea Jr, Mark S Price and David E Wemmer

Citation: BMC Pharmacology 2009 9(Suppl 1):S27

Content type: Oral presentation Published on: 11 August 2009
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A novel designer natriuretic peptide CD-NP suppresses TGF-beta 1 induced collagen Type I production in human cardiac fibroblasts

Authors: Tomoko Ichiki, Brenda K Huntley, S Jeson Sangaralingham, Horng H Chen and John C Burnett Jr

Citation: BMC Pharmacology 2009 9(Suppl 1):P27

Content type: Poster presentation Published on: 11 August 2009
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Cyclic GMP-dependent protein kinase regulation of airway smooth muscle in asthma

Authors: Masafumi Myoishi, Amy Simon and Michael E Mendelsohn

Citation: BMC Pharmacology 2009 9(Suppl 1):S28

Content type: Oral presentation Published on: 11 August 2009
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GAF domain-induced activation of phosphodiesterases 2 and 5

Authors: Ronald Jäger, Corina Russwurm, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology 2009 9(Suppl 1):P28

Content type: Poster presentation Published on: 11 August 2009
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Regulation of soluble guanylyl cyclase by phosphorylation

Authors: Zongmin Zhou, Nazish Sayed, Anastasia Pyriochou, David Fulton, Annie Beuve and Andreas Papapetropoulos

Citation: BMC Pharmacology 2009 9(Suppl 1):S29

Content type: Oral presentation Published on: 11 August 2009
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Cardioprotective effects in aged spontaneously hypertensive rats due to chronic stimulation/activation of sGC without hypotension

Authors: Emma S Jones, Barbara K Kemp-Harper, Johannes-Peter Stasch, Harald HHW Schmidt and Robert E Widdop

Citation: BMC Pharmacology 2009 9(Suppl 1):P29

Content type: Poster presentation Published on: 11 August 2009
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Nitrate-induced tolerance, toxicity and preconditioning: a rationale for reconsidering the use of these drugs

Authors: John D Parker and Tommaso Gori

Citation: BMC Pharmacology 2009 9(Suppl 1):S30

Content type: Oral presentation Published on: 11 August 2009
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Cardio-renal protection of riociguat (BAY 63-2521) in low- and high-renin models of hypertension

Authors: Philipp Kalk, Yuliya Sharkovska, Bettina Lawrenz, Michael Godes, Linda Sarah Hoffmann, Kathrin Wellkisch, Sandra Geschka, Katharina Relle, Berthold Hocher and Johannes-Peter Stasch

Citation: BMC Pharmacology 2009 9(Suppl 1):P30

Content type: Poster presentation Published on: 11 August 2009
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Janus-faced signaling of cGMP in acute lung injury

Authors: R Scott Stephens, O Rentsendorj, Eric P Schmidt, Paul Hassoun, Aigul Moldobaeva and David B Pearse

Citation: BMC Pharmacology 2009 9(Suppl 1):S31

Content type: Oral presentation Published on: 11 August 2009
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Nitroxyl, the novel redox sibling of NO, suppresses cerebrovascular NADPH oxidase

Authors: Barbara Kemp-Harper, Ravina Ravi, Michelle Bullen, Rebecca Ritchie, Christopher Sobey and Alyson Miller

Citation: BMC Pharmacology 2009 9(Suppl 1):P31

Content type: Poster presentation Published on: 11 August 2009
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Role of PKG II in osteoblast mechanotransduction

Authors: Hema Rangaswami, Nisha Marate Shunhui Zhuang, Yongchang Chen and Renate B Pilz

Citation: BMC Pharmacology 2009 9(Suppl 1):S32

Content type: Oral presentation Published on: 11 August 2009
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Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway

Authors: Hideyuki Kinoshita, Koichiro Kuwahara, Ryuji Inoue, Motohiro Nishida, Hitoshi Kurose, Shigeki Kiyonaka, Yasuo Mori, Masaki Harada, Masao Murakami, Yasuaki Nakagawa, Shinji Yasuno, Satoru Usami, Masataka Fujiwara, Yoshihiro Kuwabara, Takeya Minami, Yuko Yamada…

Citation: BMC Pharmacology 2009 9(Suppl 1):P32

Content type: Poster presentation Published on: 11 August 2009
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The PKG1 specific phosphorylation substrate cysteine-rich protein 2 knockout decreases blood pressure and intimal hyperplasia

Authors: Matthias Sausbier, Usamah Abdullah, Ulrike Sausbier, Yi-Liu Liao, Hong Zhao, Marcus Makowski, Susanne Feil, Robert Feil, Franz Hofmann, Alfred Nordheim, René Botnar and Peter Ruth

Citation: BMC Pharmacology 2009 9(Suppl 1):S33

Content type: Oral presentation Published on: 11 August 2009
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C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons

Authors: Ichiro Kishimoto, Takeshi Tokudome, Hideki Chusho, Kazuwa Nakao and Kenji Kangawa

Citation: BMC Pharmacology 2009 9(Suppl 1):P33

Content type: Poster presentation Published on: 11 August 2009
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cGMP elevation: new treatment options for lower urinary tract disorders

Authors: Peter Sandner

Citation: BMC Pharmacology 2009 9(Suppl 1):S34

Content type: Oral presentation Published on: 11 August 2009
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The ANP/cGMP/cGMP-dependent protein kinase pathway counteracts Angiotensin II-stimulated calcium mobilization in cardiac myocytes

Authors: Michael Klaiber, Katharina Völker, Birgit Gaßner, Andrea Gerling, Susanne Feil, Robert Feil and Michaela Kuhn

Citation: BMC Pharmacology 2009 9(Suppl 1):P34

Content type: Poster presentation Published on: 11 August 2009
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Progressive decline in circulating CNP with aging is associated with progressive cardiac fibrosis and myocardial impairment

Authors: Jeson Sangaralingham, Fernando L Martin, Paul M McKie, Tomoko Ichiki, Selma F Mohammed, Gerald E Harders, Elise A Oehler, Horng H Chen, Margaret M Redfield and John C Burnett Jr

Citation: BMC Pharmacology 2009 9(Suppl 1):S35

Content type: Oral presentation Published on: 11 August 2009
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Pharmacological activation of soluble guanylate cyclase activator protects the heart against isoproterenol-induced myocardial ischemia in rats

Authors: Sevil Korkmaz, Tamás Radovits, Enikő Barnucz, Kristóf Hirschberg, Philipp Neugebauer, Sivakkanan Loganathan, Stefan Zöllner, Szabolcs Páli, Beatrice Seidel, Matthias Karck and Gábor Szabó

Citation: BMC Pharmacology 2009 9(Suppl 1):P35

Content type: Poster presentation Published on: 11 August 2009
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Functional dissection of the cGK substrate IRAG using transgenic models

Authors: Jens Schlossmann, Matthias Desch, Bernhard Hieke, Katharina Salb and Elisabeth Schinner

Citation: BMC Pharmacology 2009 9(Suppl 1):S36

Content type: Oral presentation Published on: 11 August 2009
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BAY 58-2667, an NO-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts

Authors: Thomas Krieg, Yanping Liu, Thomas Rütz, Carmen Methner, Xi-Ming Yang, Stephan B Felix and James M Downey

Citation: BMC Pharmacology 2009 9(Suppl 1):P36

Content type: Poster presentation Published on: 11 August 2009
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cGMP-dependent signaling pathways in spinal pain processing

Authors: Achim Schmidtko, Wei Gao, Peter König, Sandra Heine, Matthias Sausbier, Peter Ruth, Doris Koesling, Irmgard Tegeder, Andreas Friebe and Gerd Geisslinger

Citation: BMC Pharmacology 2009 9(Suppl 1):S37

Content type: Oral presentation Published on: 11 August 2009
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Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs

Authors: Martina Krüger, Sebastian Kötter, Anika Grützner, Patrick Lang, Christian Andresen, argaret M Redfield, Elke Butt, Cris G dos Remedios and Wolfgang A Linke

Citation: BMC Pharmacology 2009 9(Suppl 1):P37

Content type: Poster presentation Published on: 11 August 2009
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Structural and mechanistic insights into cGMP signaling

Authors: Annika Rauch, Michael Russwurm, Christine Schlicker, Martina Leipelt and Clemens Steegborn

Citation: BMC Pharmacology 2009 9(Suppl 1):S38

Content type: Oral presentation Published on: 11 August 2009
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Differential effects of selective PDE5 inhibitors in rat cerebral arteries in vitro and in vivo

Authors: Christina Kruuse, Saurabh Gupta, Elisabet Nilsson, Lars Kruse and Lars Edvinsson

Citation: BMC Pharmacology 2009 9(Suppl 1):P38

Content type: Poster presentation Published on: 11 August 2009
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Kynurenine is a novel endothelium-derived vascular relaxing factor produced during inflammation

Authors: Yutang Wang, Hanzhong Liu, Gavin McKenzie, Paul K Witting, Johannes-Peter Stasch, Michael Hahn, Katherine A Jackman, Dechaboon Changsirivathanathamrong, Ben J Wu, Helen J Ball, Shane R Thomas, David S Celermajer, Andrew L Mellor, Chris G Sobey, John F Keaney Jr, Nicholas H Hunt…

Citation: BMC Pharmacology 2009 9(Suppl 1):S39

Content type: Oral presentation Published on: 11 August 2009
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From biochemical and structural studies of soluble guanylate cyclase toward drug design

Authors: Emmanuelle Laffly, Jane Macdonald and Elsa Garcin

Citation: BMC Pharmacology 2009 9(Suppl 1):P39

Content type: Poster presentation Published on: 11 August 2009
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Cyclic GMP signalling in human ES and iPS-derived vascular cells

Authors: Daisuke Taura, Masakatsu Sone, Koichiro Homma, Kenichi Yamahara and Kazuwa Nakao

Citation: BMC Pharmacology 2009 9(Suppl 1):S40

Content type: Oral presentation Published on: 11 August 2009
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cGMP kinase I regulates glucagon release

Authors: Veronika Leiss, Andreas Friebe, Franz Hofmann and Robert Lukowski

Citation: BMC Pharmacology 2009 9(Suppl 1):P40

Content type: Poster presentation Published on: 11 August 2009
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NO-insensitive sGCbeta1 H105F knockin mice: if NO has no place to go

Authors: Robrecht Thoonen, Emmanuel Buys, Anje Cauwels, Elke Rogge, Sofie Nimmegeers, Maureen Van den Hemel, Tino Hochepied, Johan Van de Voorde, Johannes-Peter Stasch and Peter Brouckaert

Citation: BMC Pharmacology 2009 9(Suppl 1):S41

Content type: Oral presentation Published on: 11 August 2009
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Phosphodiesterase-5 inhibition delays cardiac dilation and improves myocardial function in a rat model of heart failure due to chronic volume overload

Authors: Sivakkanan Loganathan, Tamás Radovits, Kristóf Hirschberg, Sevil Korkmaz, Matthias Karck and Gábor Szabó

Citation: BMC Pharmacology 2009 9(Suppl 1):P41

Content type: Poster presentation Published on: 11 August 2009
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Structural insights into sGC

Authors: Focco van den Akker, Xiaolei Ma, Faye Martin, Priyaranjan Pattanaik, Pius Padayatti, Matthew Warman and Annie Beuve

Citation: BMC Pharmacology 2009 9(Suppl 1):S42

Content type: Oral presentation Published on: 11 August 2009
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Identification of novel target proteins of cGMP/cAMP signaling pathway using cGMP/cAMP capture compound mass spectrometry (CCMS)

Authors: Yan Luo, Olivia Baessler, Mirko Glinski, Michael Sefkow, Mathias Dreger and Hubert Koester

Citation: BMC Pharmacology 2009 9(Suppl 1):P42

Content type: Poster presentation Published on: 11 August 2009
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Cross-talk of inhibitory and stimulatory signalling pathways of human platelets

Authors: Ulrich Walter and Stepan Gambaryan

Citation: BMC Pharmacology 2009 9(Suppl 1):S43

Content type: Oral presentation Published on: 11 August 2009
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Structural studies of soluble guanylate cyclase

Authors: Jane Macdonald, Emmanuelle Laffly and Elsa Garcin

Citation: BMC Pharmacology 2009 9(Suppl 1):P43

Content type: Poster presentation Published on: 11 August 2009
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A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity

Authors: Yafelle Serulle, Ipe Ninan, Daniela Puzzo, Maria McCarthy, Latika Khatri, Ottavio Arancio and Edward Ziff

Citation: BMC Pharmacology 2009 9(Suppl 1):S44

Content type: Oral presentation Published on: 11 August 2009
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Pro-B-Type natriuretic peptide: a novel, specific biomarker for detection of left ventricular dysfunction in the general community

Authors: Fima Macheret, Denise Heublein, Brian Lahr, Lisa Costello-Boerrigter, Guido Boerrigter, Paul McKie, Sharon Sandberg, Richard Rodeheffer, Alessandro Cataliotti and John C Burnett Jr

Citation: BMC Pharmacology 2009 9(Suppl 1):P44

Content type: Poster presentation Published on: 11 August 2009
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Receptor guanylyl cyclases in mammalian olfaction: from genes to function

Authors: Frank Zufall

Citation: BMC Pharmacology 2009 9(Suppl 1):S45

Content type: Oral presentation Published on: 11 August 2009
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Effects of carbon monoxide-releasing molecules on cGMP levels and soluble guanylate cyclase activity

Authors: Antonia Marazioti, Padmamalini Baskaran, Annie Beuve, Carlos Romao, Anastasia Pyriochou and Andreas Papapetropoulos

Citation: BMC Pharmacology 2009 9(Suppl 1):P45

Content type: Poster presentation Published on: 11 August 2009
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Quantification of cGMP in human plasma by isotope dilution LC-MS/MS

Authors: Jens Martens-Lobenhoffer, Christin Dautz and Stefanie M Bode-Böger

Citation: BMC Pharmacology 2009 9(Suppl 1):P46

Content type: Poster presentation Published on: 11 August 2009
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The uremic retention solute p-cresyl sulfate alters NO signal transduction by alteration of the soluble guanylate cyclase redox state

Authors: Björn KI Meijers, Constanze Meye, Johannes-Peter Stasch, Peter Gross and Pieter Evenepoel

Citation: BMC Pharmacology 2009 9(Suppl 1):P47

Content type: Poster presentation Published on: 11 August 2009
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Negative feedback regulation within NO/cGMP pathway attenuates vasodilatory response in renovascular hypertension

Authors: Evanthia Mergia, Johannes Stegbauer, Sebastian Friedrich, Ivo Quack, Lars Christian Rump and Doris Koesling

Citation: BMC Pharmacology 2009 9(Suppl 1):P48

Content type: Poster presentation Published on: 11 August 2009
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Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteosomal degradation

Authors: Sabine Meurer, Sylke Pioch, Tatjana Pabst, Nils Opitz, Peter M Schmidt, Tobias Beckhaus, Kristina Wagner, Simone Matt, Kristina Gegenbauer, Sandra Geschka, Michael Karas, Johannes-Peter Stasch, Harald HHW Schmidt and Werner Müller-Esterl

Citation: BMC Pharmacology 2009 9(Suppl 1):P49

Content type: Poster presentation Published on: 11 August 2009
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Thrombospondin-1 is a universal inhibitor of soluble guanylate cyclase activation

Authors: Thomas W Miller, Jeff S Isenberg and David D Roberts

Citation: BMC Pharmacology 2009 9(Suppl 1):P50

Content type: Poster presentation Published on: 11 August 2009
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Acute hemodynamic response to single oral doses of BAY 60-4552, a soluble guanylate cyclase stimulator, in patients with biventricular heart failure

Authors: Veselin Mitrovic, B Swidnicki, Ardeschir Ghofrani, Wolfgang Mück, Nina Kirschbaum, Joachim Mittendorf, Johannes-Peter Stasch, Georg Wensing, Reiner Frey and Silvia Lentini

Citation: BMC Pharmacology 2009 9(Suppl 1):P51

Content type: Poster presentation Published on: 11 August 2009
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Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension

Authors: Joachim Mittendorf, Stefan Weigand, Cristina Alonso-Alija, Erwin Bischoff, Achim Feurer, Michael Gerisch, Armin Kern, Andreas Knorr, Dieter Lang, Klaus Muenter, Martin Radtke, Hartmut Schirok, Karl-Heinz Schlemmer, Elke Stahl, Alexander Straub, Frank Wunder…

Citation: BMC Pharmacology 2009 9(Suppl 1):P52

Content type: Poster presentation Published on: 11 August 2009
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Sildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice

Authors: Candace M Parchen, Dao-Fu Dai, Justin M Percival, Monte Willis, Stanley C Froehner and Joseph A Beavo

Citation: BMC Pharmacology 2009 9(Suppl 1):P53

Content type: Poster presentation Published on: 11 August 2009
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Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats

Authors: Fernanda BM Priviero, Julio A Rojas-Moscoso, Alexandre S Silva, Edson Antunes and Angelina Zanesco

Citation: BMC Pharmacology 2009 9(Suppl 1):P54

Content type: Poster presentation Published on: 11 August 2009
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Synthesis and characterization of NS-2028 analogues

Authors: Anastasia Pyriochou, Athanasios Giannis and Andreas Papapetropoulos

Citation: BMC Pharmacology 2009 9(Suppl 1):P55

Content type: Poster presentation Published on: 11 August 2009
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4th International Conference of cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

BMC Pharmacology