Volume 7 Supplement 1

3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

Dresden, Germany15-17 June 2007

Page 2 of 3

In vivo evidence that cyclic GMP-dependent protein kinase G type I α mediates an anti-hypertrophic pathway in the heart

Authors: Robert M Blanton, Alexandra Dabreo, Richard H Karas and Michael E Mendelsohn

Citation: BMC Pharmacology 2007 7(Suppl 1):S26

Content type: Oral presentation Published on: 25 July 2007
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Characterization of an epitope-tagged guanylyl cyclase-A receptor

Authors: Michael Hartmann, Juliane Schröter, Viacheslav O Nikolaev, Albert Sickmann, Ruey-Bing Yang and Michaela Kuhn

Citation: BMC Pharmacology 2007 7(Suppl 1):P26

Content type: Poster presentation Published on: 25 July 2007
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Molecular steps in sGC activation

Authors: Elizabeth M Boon, Stephen PL Cary, Shirley H Huang, Jonathan A Winger, Emily R Derbyshire, Mark S Price, William K Erbil and Michael A Marletta

Citation: BMC Pharmacology 2007 7(Suppl 1):S27

Content type: Oral presentation Published on: 25 July 2007
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A luminescence based biochemical assay for soluble guanylyl cyclase

Authors: Stefan Heitmeier, Ute Schüssler, Wolfgang Schröter and Nils Burkhardt

Citation: BMC Pharmacology 2007 7(Suppl 1):P27

Content type: Poster presentation Published on: 25 July 2007
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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses endothelial dysfunction and oxidative stress associated with the metabolic syndrome

Authors: Behr-Roussel Delphine, Alexandra Oudot, Stephanie Caisey, Olivier Le Coz, Diane Gorny, Jaques Bernabé, Chris Wayman, Laurent Alexandre and Francois Giuliano

Citation: BMC Pharmacology 2007 7(Suppl 1):S28

Content type: Oral presentation Published on: 25 July 2007
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Cardiovascular effects of the soluble guanylyl cyclase activator BAY 58–2667 in anesthetized dogs

Authors: Michael Hoffmann and Uwe Thuss

Citation: BMC Pharmacology 2007 7(Suppl 1):P28

Content type: Poster presentation Published on: 25 July 2007
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Phosphorylation of cAMP hydrolyzing PDE (PDE3A) by cGMP-dependent protein kinase (PKG) in human platelets

Authors: Sergei D Rybalkin, Irina G Rybalkina and Joseph A Beavo

Citation: BMC Pharmacology 2007 7(Suppl 1):S29

Content type: Oral presentation Published on: 25 July 2007
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Increased mesangial cGMP levels prevent mesangial cell proliferation and matrix expansion in experimental glomerulonephritis

Authors: Bernd Hohenstein, Christoph Daniel, Sandra Wittmann, Andrea Braun, Johannes-Peter Stasch and Christian Hugo

Citation: BMC Pharmacology 2007 7(Suppl 1):P29

Content type: Poster presentation Published on: 25 July 2007
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Negative feedback control of the nitric oxide/cGMP pathway in smooth muscle

Authors: Jackie Corbin, Emmanuel P Bessay, Mitsi A Blount, Roya Zoraghi, Gary Z Morris, James L Weeks, Hengming Ke and Sharron H Francis

Citation: BMC Pharmacology 2007 7(Suppl 1):S30

Content type: Oral presentation Published on: 25 July 2007
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Integrin receptor subtype antagonism augments BNP-mediated cGMP generation in cultured human cardiac fibroblasts: evidence for particulate guanylate cyclase receptor and integrin receptor cross-talk

Authors: Brenda K Huntley and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P30

Content type: Poster presentation Published on: 25 July 2007
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Melanocytes: interface of cell biology and pathobiology with a focus on nitric oxide and cGMP signaling

Authors: Krassimira Ivanova, Pranab Kumar Das and Rupert Gerzer

Citation: BMC Pharmacology 2007 7(Suppl 1):S31

Content type: Oral presentation Published on: 25 July 2007
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The nitroxyl anion (HNO) donor, Angeli's salt, does not develop tolerance in vivo

Authors: Jennifer C Irvine, Barbara K Kemp-Harper and Robert E Widdop

Citation: BMC Pharmacology 2007 7(Suppl 1):P31

Content type: Poster presentation Published on: 25 July 2007
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Translational research of natriuretic peptide family

Authors: Kazuwa Nakao

Citation: BMC Pharmacology 2007 7(Suppl 1):S32

Content type: Oral presentation Published on: 25 July 2007
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Vascular smooth muscle PDE5 is much more sensitive to N-alkylated zaprinast than platelet PDE5

Authors: Jacques F Kameni-Tcheudji, Thérèse Keravis, Alain Le Bec, Luc Lebeau, Jean-Marie Strub, Alain van Dorsselaer and Claire Lugnier

Citation: BMC Pharmacology 2007 7(Suppl 1):P32

Content type: Poster presentation Published on: 25 July 2007
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Influence of heme metabolism and redox regulation of sGC in the control of vascular function

Authors: Michael S Wolin, Sachin A Gupte, Mansoor Ahmad and Christopher J Mingone

Citation: BMC Pharmacology 2007 7(Suppl 1):S33

Content type: Oral presentation Published on: 25 July 2007
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Inhibitors of cAMP and cGMP phosphodiesterases enhance neurite outgrowth from cultured cortical neurons in a PKG dependent manner

Authors: Lida Kimmel, Mary Collins, Christopher J Schmidt, Frank Menniti and Robin Kleiman

Citation: BMC Pharmacology 2007 7(Suppl 1):P33

Content type: Poster presentation Published on: 25 July 2007
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Oxidative stress induces CHIP-mediated ubiquitination and roteasomal degradation of soluble guanylyl cyclase

Authors: Sabine Meurer, Tatjana Pabst, Sylke Pioch, Nils Opitz, Peter M Schmidt, Kristina Wagner, Simone Matt, Harald HHW Schmidt and Werner Müller-Esterl

Citation: BMC Pharmacology 2007 7(Suppl 1):S34

Content type: Oral presentation Published on: 25 July 2007
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cGMP-Protein kinase G signaling pathway is involved in stimulation of Leydig cell steroidogenesis

Authors: Tatjana Kostic, Marija Janjic, Natasa Stojkov, Stanko Stojilkovic and Silvana Andric

Citation: BMC Pharmacology 2007 7(Suppl 1):P34

Content type: Poster presentation Published on: 25 July 2007
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Hsp90 and sGC-mediated vasorelaxation

Authors: John D Catravas

Citation: BMC Pharmacology 2007 7(Suppl 1):S35

Content type: Oral presentation Published on: 25 July 2007
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Vardenafil limits infarction at reperfusion in isolated rat hearts dependent on guanylyl cyclase and PKG

Authors: Thomas Krieg, Ole Maas, Ulrike Donat and Stephan B Felix

Citation: BMC Pharmacology 2007 7(Suppl 1):P35

Content type: Poster presentation Published on: 25 July 2007
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Insights into activation and dimerization of soluble guanylate cyclase

Authors: Christiane Rothkegel, Peter M Schmidt, Derek-John Atkins, Friederike Stoll, Henning Schröder, Harald HHW Schmidt and Johannes-Peter Stasch

Citation: BMC Pharmacology 2007 7(Suppl 1):S36

Content type: Oral presentation Published on: 25 July 2007
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PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system: role in pathogenesis of migraine?

Authors: Lars S Kruse, Morten Møller, Maiken Tibæk, Steen Gammeltoft, Jes Olesen and Christina Kruuse

Citation: BMC Pharmacology 2007 7(Suppl 1):P36

Content type: Poster presentation Published on: 25 July 2007
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Structural insights into sGC

Authors: Xiaolei Ma, Nazish Sayed, Annie Beuve and Focco van den Akker

Citation: BMC Pharmacology 2007 7(Suppl 1):S37

Content type: Oral presentation Published on: 25 July 2007
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Cardiorenal actions of a novel chimeric natriuretic peptide, CD-NP, as compared to C-type natriuretic peptide, in the normal dog

Authors: Candace YW Lee, Guido Boerrigter, Gail J Harty and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P37

Content type: Poster presentation Published on: 25 July 2007
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Dynamic ligand exchange as mechanism for sGC selectivity, NO activation and its reversal

Authors: Emil Martin, Vladimir Berka, Ah-Lih Tsai and Ferid Murad

Citation: BMC Pharmacology 2007 7(Suppl 1):S38

Content type: Oral presentation Published on: 25 July 2007
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Pharmacokinetic and pharmacodynamic study of a novel chimeric natriuretic peptide, CD-NP, in the normal dog

Authors: Candace YW Lee, Guido Boerrigter, Gail J Harty and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P38

Content type: Poster presentation Published on: 25 July 2007
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A new Rac-cGMP signaling pathway

Authors: Xin-Yun Huang

Citation: BMC Pharmacology 2007 7(Suppl 1):S39

Content type: Oral presentation Published on: 25 July 2007
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Effects of vardenafil, a selective phosphodiesterase-5-inhibitor, on cardiovascular function in a rat model

Authors: Sivakkanan Loganathan, Tamás Radovits, Iwan R Wirotanseng, Gábor Veres, Siegfried Hagl and Gábor Szabó

Citation: BMC Pharmacology 2007 7(Suppl 1):P39

Content type: Poster presentation Published on: 25 July 2007
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Regulation of cardiovascular physiology by cyclic GMP-dependent protein kinase Iα

Authors: Michael E Mendelsohn

Citation: BMC Pharmacology 2007 7(Suppl 1):S40

Content type: Oral presentation Published on: 25 July 2007
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Fresh look on old substances – new class of NO-independent regulators of soluble guanylyl cyclase activity and function

Authors: Emil Martin, Elena Bogatenkova, Ka Bian and Marie-Francoise Doursout

Citation: BMC Pharmacology 2007 7(Suppl 1):P40

Content type: Poster presentation Published on: 25 July 2007
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Vascular remodelling in the absence and presence of cGKI

Authors: Robert Lukowski, Dominik Bernhard, Pascal Weinmeister, Susanne Feil, Michael Gotthardt, Joachim Herz, Stefan Massberg, Franz Hofmann and Robert Feil

Citation: BMC Pharmacology 2007 7(Suppl 1):S41

Content type: Oral presentation Published on: 25 July 2007
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Supersensitivity of muscarinic receptors in rat isolated detrusor smooth muscle (DSM) after chronic nitric oxide inhibition

Authors: Fabiola Mónica, Gilberto de Nucci, Alice Bricola, Angelina Zanesco, Catarina Porto, Fernando Abdalla, Leandro Freitas, Maria Aparecida Teixeira and Edson Antunes

Citation: BMC Pharmacology 2007 7(Suppl 1):P41

Content type: Poster presentation Published on: 25 July 2007
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sGC activation promotes angiogenesis

Authors: Andreas Papapetropoulos, Anastasia Pyriochou and Zongmin Zhou

Citation: BMC Pharmacology 2007 7(Suppl 1):S42

Content type: Oral presentation Published on: 25 July 2007
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The formation of a Ca²⁺-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform

Authors: Michael Nesheim, John Samis, John Walker, Timothy Fischer, Liliana Tejidor, Greg Jones, Wim Houdijk, Alan Giles, Lev Becker, Marlys Koschinsky, Richard Wenstone, Colin Downey and Cheng Hock Toh

Citation: BMC Pharmacology 2007 7(Suppl 1):P42

Content type: Poster presentation Published on: 25 July 2007
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NO-sensitive guanylyl cyclase β1 subunit interacts with chromosomes during mitosis: novel role in the regulation of chromatin condensation

Authors: Paula Pifarré, María Antonia Baltrons, Verónca Davalos, Simon Schwartz Jr and Agustina García

Citation: BMC Pharmacology 2007 7(Suppl 1):S43

Content type: Oral presentation Published on: 25 July 2007
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FRET-based method for rapid screening of PDE-inhibitors in living cells

Authors: Viacheslav O Nikolaev, Sabine Herget and Martin J Lohse

Citation: BMC Pharmacology 2007 7(Suppl 1):P43

Content type: Poster presentation Published on: 25 July 2007
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Functional roles of isoforms of NO-sensitive guanylyl cyclase

Authors: Doris Koesling, Evanthia Mergia, Feras Taqatqeh, Thomas Mittmann, Axel Becker, Volker Hoellt and Gisela Grecksch

Citation: BMC Pharmacology 2007 7(Suppl 1):S44

Content type: Oral presentation Published on: 25 July 2007
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NPR-A gene deletion reverses vascular dysfunction associated with sepsis

Authors: Catherine M Panayiotou and Adrian J Hobbs

Citation: BMC Pharmacology 2007 7(Suppl 1):P44

Content type: Poster presentation Published on: 25 July 2007
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Novel GKAPs for cGMP-dependent protein kinase type II: identification and functional significance

Authors: Boris M Hogema and Hugo R de Jonge

Citation: BMC Pharmacology 2007 7(Suppl 1):S45

Content type: Oral presentation Published on: 25 July 2007
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Protein kinase G phosphorylates soluble guanylyl cyclase and inhibits its activity

Authors: Andreas Papapetropoulos, Zongmin Zhou, Nazish Sayed, Anastasia Pyriochou, Charis Roussos, David Fulton and Annie Beuve

Citation: BMC Pharmacology 2007 7(Suppl 1):P45

Content type: Poster presentation Published on: 25 July 2007
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cGMP kinase and food-related behaviours

Authors: Marla B Sokolowski

Citation: BMC Pharmacology 2007 7(Suppl 1):S46

Content type: Oral presentation Published on: 25 July 2007
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cGMP-dependent kinase I supports formation of associative fear memory and long-term potentiation in the lateral amygdala

Authors: Cindy Paul, Pascal Weinmeister, Robert Feil, Franz Hofmann and Thomas Kleppisch

Citation: BMC Pharmacology 2007 7(Suppl 1):P46

Content type: Poster presentation Published on: 25 July 2007
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cGMP signaling and bifurcation of sensory axons at the dorsal root entry zone of the spinal cord

Authors: Agne Stonkute, Hannes Schmidt, Rene Jüttner, Susanne Schäffer, Jens Buttgereit, Robert Feil, Franz Hofmann and Fritz G Rathjen

Citation: BMC Pharmacology 2007 7(Suppl 1):S47

Content type: Oral presentation Published on: 25 July 2007
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cGMP-dependent and -independent angiogenesis-related properties of nitric oxide

Authors: Anastasia Pyriochou, Zongmin Zhou and Andreas Papapetropoulos

Citation: BMC Pharmacology 2007 7(Suppl 1):P47

Content type: Poster presentation Published on: 25 July 2007
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Regulation of cGMP by phosphodiesterases (PDEs) in the central nervous system

Authors: Frank S Menniti, Robin J Kleiman and Christopher J Schmidt

Citation: BMC Pharmacology 2007 7(Suppl 1):S48

Content type: Oral presentation Published on: 25 July 2007
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The use of PDE5 inhibitors in the treatment of benign prostate hyperplasia and lower urinary tract symptoms: preclinical evidences

Authors: Peter Sandner, Hanna Tinel, Beatrix Stelte-Ludwig, Erwin Bischoff and Joachim Huetter

Citation: BMC Pharmacology 2007 7(Suppl 1):P48

Content type: Poster presentation Published on: 25 July 2007
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Signaling of NO/cGMP via IRAG

Authors: Jens Schlossmann

Citation: BMC Pharmacology 2007 7(Suppl 1):S49

Content type: Oral presentation Published on: 25 July 2007
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S-nitrosylation of soluble guanylyl cyclase: a novel mechanism of nitrate tolerance?

Authors: Nazish Sayed, David Kim, Walter N Durán and Annie Beuve

Citation: BMC Pharmacology 2007 7(Suppl 1):P49

Content type: Poster presentation Published on: 25 July 2007
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NO/cGMP/PKG pathway in platelets: inhibitory but not stimulatory

Authors: Stepan Gambaryan, Suzanne M Lohmann and Ulrich Walter

Citation: BMC Pharmacology 2007 7(Suppl 1):S50

Content type: Oral presentation Published on: 25 July 2007
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Desensitization of soluble guanylyl cyclase, the NO-receptor, by S-nitrosylation

Authors: Nazish Sayed, Padmamalini Baskaran, Focco van den Akker and Annie Beuve

Citation: BMC Pharmacology 2007 7(Suppl 1):P50

Content type: Poster presentation Published on: 25 July 2007
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3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

BMC Pharmacology