Volume 11 Supplement 1

5th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

Halle, Germany24-26 June 2011

Page 2 of 3

Atrial natriuretic peptide increases the albumin permeability of mouse skeletal muscle microcirculation by the caveolae-mediated transcellular pathway

Authors: Wen Chen, Birgit Gaßner, Sebastian Börner and Michaela Kuhn

Citation: BMC Pharmacology 2011 11(Suppl 1):P16

Content type: Poster presentation Published on: 1 August 2011
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The novel dual GC-A and GC-B designer natriuretic peptide, cenderitide (CD-NP), enhances the renal actions of furosemide in a model of severe heart failure

Authors: Lisa C Costello-Boerrigter, Guido Boerrigter, Sarah Mangiafico, Alessandro Cataliotti and John C Burnett Jr

Citation: BMC Pharmacology 2011 11(Suppl 1):P17

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Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure

Authors: Lisa C Costello-Boerrigter, John A Schirger, Wayne L Miller, Guido Boerrigter, Horng H Chen, Ruth Kempf, Candace Y Lee and John C Burnett Jr

Citation: BMC Pharmacology 2011 11(Suppl 1):P18

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Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice

Authors: Sarah Cosyns, Johannes-Peter Stasch, Peter Brouckaert and Romain A Lefebvre

Citation: BMC Pharmacology 2011 11(Suppl 1):P19

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Study on the involvement of soluble guanylyl cyclase and its different isoforms in carbon monoxide and carbon monoxide releasing molecule-2 induced vasodilatation

Authors: Kelly Decaluwé, Bart Pauwels, Sara Verpoest, Robrecht Thoonen, Emmanuel Buys, Peter Brouckaert and Johan Van de Voorde

Citation: BMC Pharmacology 2011 11(Suppl 1):P20

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Interaction between bradykinin and urodilatin - a possible mechanism of clinical relevance

Authors: Marina Dobrivojević, Aleksandra Sinđić, Bojana Nikitović, Bayram Edemir, Eberhard Schlatter, Wolf-Georg Forssmann and Jochen R Hirsch

Citation: BMC Pharmacology 2011 11(Suppl 1):P21

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Cenderitide, a novel dual GC-A and GC-B receptor activator, is a potent chronic cardiorenal fibroinhibiting peptide which suppresses aldosterone and reduces proteinuria in models of ardiorenal fibrosis

Authors: Fernando L Martin, Paul M McKie, Jeson S Sangaralingham, Tomoko Ichiki, Gerald E Harders, Horng H Chen and John C Burnett Jr

Citation: BMC Pharmacology 2011 11(Suppl 1):P22

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PDE expression and contractility of seminiferous tubules of the human testis

Authors: Caroline Feuerstacke, Sabine Tasch, Johanna Volkmann, Dieter Müller and Ralf Middendorff

Citation: BMC Pharmacology 2011 11(Suppl 1):P23

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Transformer (Tra2β): master regulator of myosin phosphatase alternative splicing and smooth muscle responses to NO/cGMP signaling

Authors: Steven A Fisher, Ylva Mende, Brunhilde Wirth and Kang Fu

Citation: BMC Pharmacology 2011 11(Suppl 1):P24

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No pharmacodynamic (PD) and pharmacokinetic (PK) interaction of riociguat (BAY 63-2521) and aspirin

Authors: Reiner Frey, Wolfgang Mück, Sigrun Unger, Michael Reber, Jörn Krätzschmar, Corina Becker and Georg Wensing

Citation: BMC Pharmacology 2011 11(Suppl 1):P25

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Antiplatelet effects of aspirin are not affected by the soluble guanylate cyclase activator cinaciguat (BAY 58-2667)

Authors: Reiner Frey, Wolfgang Mueck, Michael Becka, Joern Kraetzschmar and Georg Wensing

Citation: BMC Pharmacology 2011 11(Suppl 1):P26

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Specific PKG inhibitors: do they really exist?

Authors: Stepan Gambaryan, Elke Butt, Joerg Geiger, Suzanne M Lohmann and Ulrich Walter

Citation: BMC Pharmacology 2011 11(Suppl 1):P27

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Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats

Authors: Sandra Geschka, Axel Kretschmer, Yuliya Sharkovska, Oleg V Evgenov, Andreas Hucke, Bettina Lawrenz, Berthold Hocher and Johannes-Peter Stasch

Citation: BMC Pharmacology 2011 11(Suppl 1):P28

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Rosiglitazone improves the natriuretic response to atrial natriuretic peptide in rats with experimental congestive heart failure: possible involvement of a post-guanylate cyclase mechanism

Authors: Ilia Goltsman, Elena Ovcharenko, Aaron Hoffman, Giora Feuerstein, Zaid Abassi and Joseph Winaver

Citation: BMC Pharmacology 2011 11(Suppl 1):P29

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Fertility in male mice lacking NO-sensitive guanylyl cyclase

Authors: Dieter Groneberg, Peter König and Andreas Friebe

Citation: BMC Pharmacology 2011 11(Suppl 1):P30

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Biomarkers in two different animal models of pulmonary arterial hypertension (PAH) under treatment with a cGMP enhancing substance

Authors: Julia Grupe, Andrea Neumann, Johannes-Peter Stasch and Kirsten Leineweber

Citation: BMC Pharmacology 2011 11(Suppl 1):P31

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New vitamin B₁₂ derivatives activates sGC

Authors: Dorota Gryko and Emil Martin

Citation: BMC Pharmacology 2011 11(Suppl 1):P32

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Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension

Authors: Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi, Russell Araki, Jennifer Villarreal, Glenmar Obedencio, Anne Kanta, Erik Sandvick, Craig Hill, Kevin Dement, Uwe Klein, Donavon McConn, William Martin and Sharath S Hegde

Citation: BMC Pharmacology 2011 11(Suppl 1):P33

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Inhibitors of the phosphodiesterase 2 increased axonal fibre growth in a dopaminergic organotypic ex vivo slice co-culture model

Authors: Claudia Heine, Nico Scherf, Katja Sygnecka, Ute Egerland, Thorsten Hage and Heike Franke

Citation: BMC Pharmacology 2011 11(Suppl 1):P34

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Role of NO/cGMP signalling in VEGF-mediated angiogenesis

Authors: Ronald Jäger, Dieter Groneberg and Andreas Friebe

Citation: BMC Pharmacology 2011 11(Suppl 1):P35

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Activation of PDE10 and PDE11

Authors: Ronald Jäger, Corina Russwurm, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology 2011 11(Suppl 1):P36

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cGMP and cAMP differentially regulate differentiation and function of brown adipocytes

Authors: Katja Jennissen, Bodo Haas, Wolfram S Kunz and Alexander Pfeifer

Citation: BMC Pharmacology 2011 11(Suppl 1):P37

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NO-sensitive guanylyl cyclase is expressed in pericytes but absent from endothelial cells in the murine lung

Authors: Peter König, Dieter Groneberg, Roland Jäger and Andreas Friebe

Citation: BMC Pharmacology 2011 11(Suppl 1):P38

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Effects of riociguat in severe experimental pulmonary hypertension

Authors: Baktybek Kojonazarov, Michaela Lang, Norbert Weissmann, Friedrich Grimminger, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani and Ralph Schermuly

Citation: BMC Pharmacology 2011 11(Suppl 1):P39

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cGMP signals in smooth muscle cells and cardiac myocytes

Authors: Christian Krawutschke, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology 2011 11(Suppl 1):P40

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Inhaled and intravenous application of a stimulator of the soluble guanylate cyclase (BAY 41-8543) reduces pulmonary vascular resistance in a model of septic shock

Authors: Nils Kronas, Birte Peters, Alwin E Goetz and Jens C Kubitz

Citation: BMC Pharmacology 2011 11(Suppl 1):P41

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Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries –relevant to migraine?

Authors: Christina Kruuse, Saurabh Gupta, Elisabeth Nilsson, Lars Kruse and Lars Edvinsson

Citation: BMC Pharmacology 2011 11(Suppl 1):P42

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The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats

Authors: Michaela Lang, Baktybek Kojonazarov, Norbert Weissmann, Friedrich Grimminger, Johannes-Peter Stasch, Werner Seeger, Hossein Ardeschir Ghofrani and Ralph Schermuly

Citation: BMC Pharmacology 2011 11(Suppl 1):P43

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Nitrergic relaxation of gastrointestinal smooth muscle: role of interstitial cells of Cajal and smooth muscle cells

Authors: Barbara Lies, Dieter Groneberg, Dieter Saur, Peter König and Andreas Friebe

Citation: BMC Pharmacology 2011 11(Suppl 1):P44

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cGMP-dependent protein kinase from Toxoplasma gondii: functional expression in E. coli and molecular characterization

Authors: Caitlin J McFarland, Christian K Nickl, Brent W Osborne, Indra Neil Sarkar and Wolfgang R Dostmann

Citation: BMC Pharmacology 2011 11(Suppl 1):P45

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Cyclic GMP generated by natriuretic peptide receptor B enhances β₁-adrenoceptor signaling in normal and failing hearts

Authors: Silja Meier, Jan Magnus Aronsen, Ivar Sjaastad, Finn Olav Levy, Tor Skomedal, Jan-Bjørn Osnes and Eirik Qvigstad

Citation: BMC Pharmacology 2011 11(Suppl 1):P46

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Acute effects of phosphodiesterase 5 (PDE5) inhibition, ANP and NO on epididymal contractility are preserved despite chronic PDE5 exposure

Authors: Andrea Mietens, Caroline Feuerstacke, Sabine Tasch, Gerrit Eichner, Ralph Theo Schermuly, Friedrich Grimminger, Dieter Müller and Ralf Middendorff

Citation: BMC Pharmacology 2011 11(Suppl 1):P47

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Protein Kinase G is a key regulator of murine white adipogenesis

Authors: Michaela M Mitschke, Daniela Scholz, Katrin Zimmermann, Peter Mayer, Bodo Haas, Alexander Pfeifer and Ana Kilic

Citation: BMC Pharmacology 2011 11(Suppl 1):P48

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The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle

Authors: Lise Román Moltzau, Jan Magnus Aronsen, Silja Meier, Cam Nguyen, Geir Christensen, Ivar Sjaastad, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy and Eirik Qvigstad

Citation: BMC Pharmacology 2011 11(Suppl 1):P49

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A novel natriuretic peptide

Authors: Hanna Höfeld, Fritz Buck, Ralf Middendorff and Dieter Müller

Citation: BMC Pharmacology 2011 11(Suppl 1):P50

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Distinct ageing- and androgen-dependent effects on cGMP signalling proteins in three male rat urogenital organs (bladder, prostate, epididymis)

Authors: Dieter Müller, Michail S Davidoff and Ralf Middendorff

Citation: BMC Pharmacology 2011 11(Suppl 1):P51

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Tissue- and development-specific glycosylation states of the natriuretic peptide receptors guanylyl cyclase-A (GC-A) and GC-B

Authors: Dieter Müller, Mirjam Hildebrand, Jörn Lübberstedt and Ralf Middendorff

Citation: BMC Pharmacology 2011 11(Suppl 1):P52

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A structural analysis of the regulatory domain from the cGMP-dependent protein kinase Iα

Authors: Brent W Osborne, Andrew T Menke, Donald K Blumenthal and Wolfgang R Dostmann

Citation: BMC Pharmacology 2011 11(Suppl 1):P53

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Design and development of novel non-peptide agonists at NPR-C

Authors: Filipa Mota Quinteiro, Paul Gane, Anne-Sophie Rebstock, Roberta Worthington, Michela Simone, Snezana Djordevic, Adrian Hobbs and David Selwood

Citation: BMC Pharmacology 2011 11(Suppl 1):P54

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NO-donors induce cross talk between cGMP and cAMP in signalling to human atrial L-type Ca²⁺ current

Authors: Nadiia Rozmaritsa, Torsten Christ, Erich Wettwer and Ursula Ravens

Citation: BMC Pharmacology 2011 11(Suppl 1):P55

Content type: Poster presentation Published on: 1 August 2011
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Comparative analysis of PDE10A isoforms

Authors: Corina Russwurm, Ronald Jäger, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology 2011 11(Suppl 1):P56

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Calcium/Calpain mediated regulation of cyclic nucleotide phosphodiesterases, PDE3A and PDE5, in human platelets

Authors: Irina G Rybalkina, Masami Shimizu-Albergine and Sergei D Rybalkin

Citation: BMC Pharmacology 2011 11(Suppl 1):P57

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Function of IRAG and the phosphorylation of the InsP₃R-I for the NO/cGMP-dependent inhibition of platelet aggregation

Authors: Katharina Salb, Elisabeth Schinner and Jens Schlossmann

Citation: BMC Pharmacology 2011 11(Suppl 1):P58

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Experimental evidence that a combination of sGC stimulator BAY 60-4552 and PDE5 inhibitor vardenafil could salvage ED-patients with insufficient response to PDE5 inhibitors after cavernous nerve injury

Authors: Alexandra Oudot, Delphine Behr-Roussel, Sarah Poirier, Jacques Bernabé, Peter Sandner and François Giuliano

Citation: BMC Pharmacology 2011 11(Suppl 1):P59

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C-Type natriuretic peptide: a potential urinary biomarker for renal remodeling and fibrosis during aging

Authors: Jeson S Sangaralingham, Denise M Heublein, Joseph P Grande, Alessandro Cataliotti, Andrew D Rule, Paul M McKie, Fernando L Martin and John C Burnett Jr

Citation: BMC Pharmacology 2011 11(Suppl 1):P60

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Pharmacokinetic analysis of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in individuals with renal impairment compared to healthy controls

Authors: Christian Scheerans, Martin Blunck, Wolfgang Mueck and Reiner Frey

Citation: BMC Pharmacology 2011 11(Suppl 1):P61

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Suppression of kidney fibrosis by cGMP-dependent protein kinase I

Authors: Elisabeth Schinner, Armin Kurtz, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology 2011 11(Suppl 1):P62

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PDE2, a component of the NO/cGMP signalling in the hippocampus

Authors: Isabel Schönle, Angela Neitz, Thomas Mittmann, Doris Koesling and Evanthia Mergia

Citation: BMC Pharmacology 2011 11(Suppl 1):P63

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Does a reduction of vascular relaxation promote hypertension?

Authors: Kathrin Schulte, Doris Koesling and Evanthia Mergia

Citation: BMC Pharmacology 2011 11(Suppl 1):P64

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cGMP and PKGI are required for vascular BMP signaling

Authors: Raphaela Schwappacher, Thuan Diep, Gerry Boss and Renate Pilz

Citation: BMC Pharmacology 2011 11(Suppl 1):P65

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5th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

BMC Pharmacology