Table 3 AUC ratios in selected tissues of treated (T; carrageenan injected) and control (C; saline injected) rats after a 2 mg/kg p.o. dose of [14C]diclofenac sodium.
AUC(0-tlast) h*(nmol/g) | Treated group T | Control group C | Ratio T/C |
|---|---|---|---|
Control footpads | 0.92* | 1.10 | 0.82 |
Injected footpads | 16.00* | 0.30 | 53.00 |
Injected nape neck | 20.00 | 0.77 | 26.00 |
Blood | 27.00 | 22.00 | 1.20 |
Kidney (cortex) | 105.00 | 88.00 | 1.20 |
Liver | 62.00 | 45.00 | 1.40 |