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Table 3 AUC ratios in selected tissues of treated (T; carrageenan injected) and control (C; saline injected) rats after a 2 mg/kg p.o. dose of [14C]diclofenac sodium.

From: Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats

AUC(0-tlast) h*(nmol/g) Treated group T Control group C Ratio T/C
Control footpads 0.92* 1.10 0.82
Injected footpads 16.00* 0.30 53.00
Injected nape neck 20.00 0.77 26.00
Blood 27.00 22.00 1.20
Kidney (cortex) 105.00 88.00 1.20
Liver 62.00 45.00 1.40
  1. The ratio in the treated group between the injected footpads and the control footpads (*) amounts to 17.