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Table 2 Pharmacokinetic parameters of total radiolabeled components in selected tissues/matrices, calculated from the radioactivity concentrations determined by QWBA after a 2 mg/kg oral dose of [14C]diclofenac sodium in treated rats (n = 3 animals/time point) and in control rats (n = 1 animal/time point).

From: Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats

Treated rats (Carrageenan injected) tmax (h) Cmax (nmol/g) AUC(0-tlast) (h*(nmol/g)) tlast (h) t1/2 (h)
Control footpads 1 0.16 0.92 8 1.80
Inflamed footpads 4 1.30 16.00 24 5.30
Inflamed nape neck 8 1.30 20.00 24 7.10
Blood 4 2.20 27.00 24 5.10
Kidney (cortex) 4 9.80 105.00 24 5.20
Liver 4 5.40 62.00 24 5.70
Control rats (Saline injected) tmax (h) Cmax (nmol/g) AUC(0-tlast) (h*(nmol/g)) tlast (h) t1/2 (h)
Control footpads 1 0.20 1.1 8 2.60
Injected footpads 1 0.12 0.30 4 1.60
Injected nape neck 1 0.18 0.77 8 2.90
Blood 4 1.90 22.00 24 4.90
Kidney (cortex) 4 8.20 88.00 24 5.30
Liver 4 4.00 45.00 24 5.50