Table 2 Pharmacokinetic parameters of total radiolabeled components in selected tissues/matrices, calculated from the radioactivity concentrations determined by QWBA after a 2 mg/kg oral dose of [14C]diclofenac sodium in treated rats (n = 3 animals/time point) and in control rats (n = 1 animal/time point).
Treated rats (Carrageenan injected) | tmax (h) | Cmax (nmol/g) | AUC(0-tlast) (h*(nmol/g)) | tlast (h) | t1/2 (h) |
|---|---|---|---|---|---|
Control footpads | 1 | 0.16 | 0.92 | 8 | 1.80 |
Inflamed footpads | 4 | 1.30 | 16.00 | 24 | 5.30 |
Inflamed nape neck | 8 | 1.30 | 20.00 | 24 | 7.10 |
Blood | 4 | 2.20 | 27.00 | 24 | 5.10 |
Kidney (cortex) | 4 | 9.80 | 105.00 | 24 | 5.20 |
Liver | 4 | 5.40 | 62.00 | 24 | 5.70 |
Control rats (Saline injected) | tmax (h) | Cmax (nmol/g) | AUC(0-tlast) (h*(nmol/g)) | tlast (h) | t1/2 (h) |
Control footpads | 1 | 0.20 | 1.1 | 8 | 2.60 |
Injected footpads | 1 | 0.12 | 0.30 | 4 | 1.60 |
Injected nape neck | 1 | 0.18 | 0.77 | 8 | 2.90 |
Blood | 4 | 1.90 | 22.00 | 24 | 4.90 |
Kidney (cortex) | 4 | 8.20 | 88.00 | 24 | 5.30 |
Liver | 4 | 4.00 | 45.00 | 24 | 5.50 |