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Table 1 Tissue concentrations of total radiolabeled components at 1, 4, 8 and 24 h after oral administration of [14C]diclofenac sodium at a dose of 2 mg/kg to male rats injected with carrageenan (T) or saline (C) into the left front footpad and the left hind paw.

From: Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats

  Concentration of total radiolabeled components (nmol/g)
  1 hour 4 hours 8 hours 24 hours
Tissue T C T C T C T C
Injection site nape neck 0.79 ± 0.12 0.18 1.20 ± 0.30 tc 1.30 ± 0.10 tc 0.20 ± 0.04 nd
Untreated footpads 0.16 ± 0.04 0.20 0.15 ± 0.10 0.20 tc nd nd nd
Injection site footpads 1.00 ± 0.23 0.12 1.30 ± 0.5 nd 0.84 ± 0.10 nd tc nd
Adrenal (cortex) 1.00 ± 0.32 0.29 0.94 ± 0.40 0.87 0.61 ± 0.10 0.59 tc nd
Bile 34.00 ± 6.25 20.00 34.00 ± 16.40 12.00 15.00 ± 3.40 7.50 1.60 ± 0.22 1.40
Blood 1.60 ± 0.27 1.00 2.20 ± 1.10 1.90 1.50 ± 0.20 1.20 0.15 ± 0.02 0.11
Bone mineral tc tc tc tc tc tc na na
Brain tc tc tc tc tc na tc na
Cartilage tc tc tc tc tc na na na
Eye (lens) tc tc tc tc tc tc tc na
Eye (vitreous body) tc tc tc tc tc tc tc na
Fat (brown) 0.69 ± 0.13 0.45 0.73 ± 0.30 0.81 0.46 ± 0.10 0.32 tc na
Fat (white) tc tc 0.12 0.15 tc tc tc na
Heart 0.86 ± 0.13 0.52 1.00 ± 0.50 1.00 0.68 ± 0.10 0.56 tc na
Kidney 11.00 ± 1.81 5.20 17.0 ± 5.50 11.00 9.10 ± 1.60 7.9 1.70 ± 0.09 1.20
Liver 4.50 ± 0.85 3.50 5.40 ± 1.10 3.90 3.0 ± 0.60 2.1 0.46 ± 0.05 0.31
Lung 1.20 ± 0.14 0.69 1.50 ± 0.70 1.30 1.00 ± 0.10 1.0 0.12 ± 0.01 0.10
Muscle 0.17 ± 0.04 0.11 0.22 ± 0.10 0.16 0.13 ± 0.01 0.12 tc T
Oesophagus 5.00 ± 1.03 9.20 3.50 ± 1.43 1.50 0.33 ± 0.15 0.39 na na
Penis 0.95 ± 0.15 0.42 7.00 ± 5.27 1.10 1.20 ± 0.11 0.65 0.27 ± 0.08 0.17
Seminal vesicle tc tc tc tc tc tc na nd
Spinal Cord tc tc tc tc tc tc na nd
Thyroid glands 0.86 ± 0.21 0.59 0.58 ± 0.11 0.60 0.46 ± 0.03 0.44 tc tc
Tooth pulp 1.20 ± 0.03 0.76 1.20 ± 0.23 1.00 1.00 ± 0.12 0.98 0.13 ± 0.04 0.10
  1. na: not applicable, nd: not detected (< limit of detection 0.034 nmol/g), tc: Traces (between limit of detection and limit of quantification (0.10 nmol/g))
  2. Values are mean ± standard deviation (SD)for the T (n = 3) and mean value in C (n = 1).