|
Concentration of total radiolabeled components (nmol/g)
|
---|
|
1 hour
|
4 hours
|
8 hours
|
24 hours
|
---|
Tissue
|
T
|
C
|
T
|
C
|
T
|
C
|
T
|
C
|
Injection site nape neck
|
0.79 ± 0.12
|
0.18
|
1.20 ± 0.30
|
tc
|
1.30 ± 0.10
|
tc
|
0.20 ± 0.04
|
nd
|
Untreated footpads
|
0.16 ± 0.04
|
0.20
|
0.15 ± 0.10
|
0.20
|
tc
|
nd
|
nd
|
nd
|
Injection site footpads
|
1.00 ± 0.23
|
0.12
|
1.30 ± 0.5
|
nd
|
0.84 ± 0.10
|
nd
|
tc
|
nd
|
Adrenal (cortex)
|
1.00 ± 0.32
|
0.29
|
0.94 ± 0.40
|
0.87
|
0.61 ± 0.10
|
0.59
|
tc
|
nd
|
Bile
|
34.00 ± 6.25
|
20.00
|
34.00 ± 16.40
|
12.00
|
15.00 ± 3.40
|
7.50
|
1.60 ± 0.22
|
1.40
|
Blood
|
1.60 ± 0.27
|
1.00
|
2.20 ± 1.10
|
1.90
|
1.50 ± 0.20
|
1.20
|
0.15 ± 0.02
|
0.11
|
Bone mineral
|
tc
|
tc
|
tc
|
tc
|
tc
|
tc
|
na
|
na
|
Brain
|
tc
|
tc
|
tc
|
tc
|
tc
|
na
|
tc
|
na
|
Cartilage
|
tc
|
tc
|
tc
|
tc
|
tc
|
na
|
na
|
na
|
Eye (lens)
|
tc
|
tc
|
tc
|
tc
|
tc
|
tc
|
tc
|
na
|
Eye (vitreous body)
|
tc
|
tc
|
tc
|
tc
|
tc
|
tc
|
tc
|
na
|
Fat (brown)
|
0.69 ± 0.13
|
0.45
|
0.73 ± 0.30
|
0.81
|
0.46 ± 0.10
|
0.32
|
tc
|
na
|
Fat (white)
|
tc
|
tc
|
0.12
|
0.15
|
tc
|
tc
|
tc
|
na
|
Heart
|
0.86 ± 0.13
|
0.52
|
1.00 ± 0.50
|
1.00
|
0.68 ± 0.10
|
0.56
|
tc
|
na
|
Kidney
|
11.00 ± 1.81
|
5.20
|
17.0 ± 5.50
|
11.00
|
9.10 ± 1.60
|
7.9
|
1.70 ± 0.09
|
1.20
|
Liver
|
4.50 ± 0.85
|
3.50
|
5.40 ± 1.10
|
3.90
|
3.0 ± 0.60
|
2.1
|
0.46 ± 0.05
|
0.31
|
Lung
|
1.20 ± 0.14
|
0.69
|
1.50 ± 0.70
|
1.30
|
1.00 ± 0.10
|
1.0
|
0.12 ± 0.01
|
0.10
|
Muscle
|
0.17 ± 0.04
|
0.11
|
0.22 ± 0.10
|
0.16
|
0.13 ± 0.01
|
0.12
|
tc
|
T
|
Oesophagus
|
5.00 ± 1.03
|
9.20
|
3.50 ± 1.43
|
1.50
|
0.33 ± 0.15
|
0.39
|
na
|
na
|
Penis
|
0.95 ± 0.15
|
0.42
|
7.00 ± 5.27
|
1.10
|
1.20 ± 0.11
|
0.65
|
0.27 ± 0.08
|
0.17
|
Seminal vesicle
|
tc
|
tc
|
tc
|
tc
|
tc
|
tc
|
na
|
nd
|
Spinal Cord
|
tc
|
tc
|
tc
|
tc
|
tc
|
tc
|
na
|
nd
|
Thyroid glands
|
0.86 ± 0.21
|
0.59
|
0.58 ± 0.11
|
0.60
|
0.46 ± 0.03
|
0.44
|
tc
|
tc
|
Tooth pulp
|
1.20 ± 0.03
|
0.76
|
1.20 ± 0.23
|
1.00
|
1.00 ± 0.12
|
0.98
|
0.13 ± 0.04
|
0.10
|
- na: not applicable, nd: not detected (< limit of detection 0.034 nmol/g), tc: Traces (between limit of detection and limit of quantification (0.10 nmol/g))
- Values are mean ± standard deviation (SD)for the T (n = 3) and mean value in C (n = 1).