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Table 1 Tissue concentrations of total radiolabeled components at 1, 4, 8 and 24 h after oral administration of [14C]diclofenac sodium at a dose of 2 mg/kg to male rats injected with carrageenan (T) or saline (C) into the left front footpad and the left hind paw.

From: Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats

 

Concentration of total radiolabeled components (nmol/g)

 

1 hour

4 hours

8 hours

24 hours

Tissue

T

C

T

C

T

C

T

C

Injection site nape neck

0.79 ± 0.12

0.18

1.20 ± 0.30

tc

1.30 ± 0.10

tc

0.20 ± 0.04

nd

Untreated footpads

0.16 ± 0.04

0.20

0.15 ± 0.10

0.20

tc

nd

nd

nd

Injection site footpads

1.00 ± 0.23

0.12

1.30 ± 0.5

nd

0.84 ± 0.10

nd

tc

nd

Adrenal (cortex)

1.00 ± 0.32

0.29

0.94 ± 0.40

0.87

0.61 ± 0.10

0.59

tc

nd

Bile

34.00 ± 6.25

20.00

34.00 ± 16.40

12.00

15.00 ± 3.40

7.50

1.60 ± 0.22

1.40

Blood

1.60 ± 0.27

1.00

2.20 ± 1.10

1.90

1.50 ± 0.20

1.20

0.15 ± 0.02

0.11

Bone mineral

tc

tc

tc

tc

tc

tc

na

na

Brain

tc

tc

tc

tc

tc

na

tc

na

Cartilage

tc

tc

tc

tc

tc

na

na

na

Eye (lens)

tc

tc

tc

tc

tc

tc

tc

na

Eye (vitreous body)

tc

tc

tc

tc

tc

tc

tc

na

Fat (brown)

0.69 ± 0.13

0.45

0.73 ± 0.30

0.81

0.46 ± 0.10

0.32

tc

na

Fat (white)

tc

tc

0.12

0.15

tc

tc

tc

na

Heart

0.86 ± 0.13

0.52

1.00 ± 0.50

1.00

0.68 ± 0.10

0.56

tc

na

Kidney

11.00 ± 1.81

5.20

17.0 ± 5.50

11.00

9.10 ± 1.60

7.9

1.70 ± 0.09

1.20

Liver

4.50 ± 0.85

3.50

5.40 ± 1.10

3.90

3.0 ± 0.60

2.1

0.46 ± 0.05

0.31

Lung

1.20 ± 0.14

0.69

1.50 ± 0.70

1.30

1.00 ± 0.10

1.0

0.12 ± 0.01

0.10

Muscle

0.17 ± 0.04

0.11

0.22 ± 0.10

0.16

0.13 ± 0.01

0.12

tc

T

Oesophagus

5.00 ± 1.03

9.20

3.50 ± 1.43

1.50

0.33 ± 0.15

0.39

na

na

Penis

0.95 ± 0.15

0.42

7.00 ± 5.27

1.10

1.20 ± 0.11

0.65

0.27 ± 0.08

0.17

Seminal vesicle

tc

tc

tc

tc

tc

tc

na

nd

Spinal Cord

tc

tc

tc

tc

tc

tc

na

nd

Thyroid glands

0.86 ± 0.21

0.59

0.58 ± 0.11

0.60

0.46 ± 0.03

0.44

tc

tc

Tooth pulp

1.20 ± 0.03

0.76

1.20 ± 0.23

1.00

1.00 ± 0.12

0.98

0.13 ± 0.04

0.10

  1. na: not applicable, nd: not detected (< limit of detection 0.034 nmol/g), tc: Traces (between limit of detection and limit of quantification (0.10 nmol/g))
  2. Values are mean ± standard deviation (SD)for the T (n = 3) and mean value in C (n = 1).