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Table 4 Direct effects of rapacuronium on [35S]GTPγS binding

From: Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors

 

M1

M2

M3

M4

M5

pEC50

4.30 ± 0.04

4.55 ± 0.04

4.12 ± 0.03

4.44 ± 0.04

4.21 ± 0.04

EMAX

0.76 ± 0.08

0.84 ± 0.06

0.75 ± 0.07

0.86 ± 0.06

0.75 ± 0.07

  1. Negative logarithms of half effective concentrations (pEC50) and EMAX of rapacuronium on [35S]GTPγS binding were obtained by fitting Eq. 5 to the data from the measurements of [35S]GTPγS binding in the presence of rapacuronium in concentrations ranging from 10-8 to 10-3 M normalized to the absence of rapacuronium (Figure 6, open squares). Values are means ± SE of fits to 3 independent experiments performed in quadruplicates.
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BMC Pharmacology

ISSN: 1471-2210