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Table 4 Activation of muscarinic M1 receptors by analogues of AC-260584 as measured by R-SAT

From: Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands

 

M1 Agonist RSAT

 

pEC50

%Efficacy

AC-260515

6.6 ± 0.2

66 ± 16

AC-262469

7.2 ± 0

107 ± 16

AC-260977

7.7 ± 0.1

107 ± 10

  1. Activities of AC-260584 analogues on human M1 receptors were assessed using R-SAT in transiently transfected NIH-3T3 cells. Data presented are mean ± SD from 5-7 independent experiments carried out in triplicate.