Table 1 Activation of muscarinic M1 receptors as measured by R-SAT® and PI assays
From: Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands
| Â | M1 Agonist RSAT | PI Hydrolysis | ||
|---|---|---|---|---|
| Â | pEC50 | % Efficacy | pEC50 | % Efficacy |
Carbachol | 6.2 ± 0.3 | 100 ± 10 | 6 ± 0.1 | 100 ± 3 |
Oxotremorine-M | 7.4 ± 0.3 | 105 ± 13 | 7.0 ± 0.1 | 106 ± 7 |
Pilocarpine | 5.7 ± 0.2 | 93 ± 15 | 6.2 ± 0.9 | 97 ± 31 |
Xanomeline | 7.4 ± 0.5 | 120 ± 21 | 8.4 ± 0.2 | 99 ± 12 |
NDMC | 7.4 ± 0.2 | 76 ± 13 | 7.1 ± 0.4 | 67 ± 23 |
AC-42 | 6.7 ± 0.3 | 62 ± 14 | 6.5 ± 0.5 | 79 ± 14 |
AC-260584 | 7.6 ± 0.4 | 102 ± 21 | 7.7 ± 0.3 | 90 ± 17 |