Figure 4
From: Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands
Treatment with hypertonic sucrose blocked internalization induced by all ligands studies. Cells were treated without (A) or with (B) 0.4 M sucrose during treatment with the various ligands at indicated concentrations. Receptors remaining at the cell surface were quantitated. Graphs are mean results (± S.D.) from test compounds run in triplicate in a representative experiment repeated 2 times with similar results.