Table 1 The effects of psychotropic drugs on the expression of cholesterol biosynthesis and transport genes in cultured human glioma (GaMg) cells.

Clozapine (25 μM)

6 h

2.4 ± 0.1**

1.2 ± 0.1

1.0 ± 0.02

1.1 ± 0.04

1.2 ± 0.1

1.2 ± 0.1

1.2 ± 0.03*

12 h

2.2 ± 0.1**

1.8 ± 0.1**

1.5 ± 0.1

1.1 ± 0.03

1.3 ± 0.01*

1.0 ± 0.1

1.0 ± 0.03

24 h

2.1 ± 0.1**

2.2 ± 0.2**

1.2 ± 0.2

1.6 ± 0.1*

1.9 ± 0.1**

1.5 ± 0.3

1.4 ± 0.02**

48 h

2.2 ± 0.1**

4.5 ± 0.1**

2.6 ± 0.2**

2.5 ± 0.1**

2.6 ± 0.1**

1.1 ± 0.04

1.3 ± 0.02**

Olanzapine (10 μM)

6 h

1.8 ± 0.3*

1.2 ± 0.1

0.9 ± 0.2

1.2 ± 0.2

0.9 ± 0.3

1.1 ± 0.02

1.2 ± 0.09

12 h

1.3 ± 0.05**

1.1 ± 0.1

0.9 ± 0.1

0.9 ± 0.1

1.0 ± 0.02

0.8 ± 0.03*

1.1 ± 0.06

24 h

1.4 ± 0.06**

1.5 ± 0.4

1.4 ± 0.06**

1.3 ± 0.05**

1.3 ± 0.02**

1.0 ± 0.1

1.3 ± 0.04*

48 h

1.1 ± 0.05*

1.5 ± 0.1*

1.2 ± 0.02**

1.0 ± 0.1

1.2 ± 0.04**

1.1 ± 0.05

1.0 ± 0.04

Haloperidol (10 μM)

6 h

2.1 ± 0.2**

1.2 ± 0.1

0.6 ± 0.06**

1.2 ± 0.1

1.0 ± 0.1

0.9 ± 0.07

1.1 ± 0.01

12 h

2.1 ± 0.1**

1.5 ± 0.2

0.3 ± 0.03**

1.1 ± 0.02*

1.2 ± 0.05*

0.6 ± 0.07**

0.8 ± 0.07*

24 h

2.2 ± 0.04**

2.3 ± 0.2**

0.3 ± 0.03**

1.7 ± 0.04**

1.8 ± 0.04**

1.1 ± 0.05

1.2 ± 0.3

48 h

1.8 ± 0.01**

2.4 ± 0.2**

0.3 ± 0.04**

1.5 ± 0.07**

1.8 ± 0.06**

1.0 ± 0.03

1.1 ± 0.04

Imipramine (10 μM)

6 h

2.0 ± 0.1**

1.2 ± 0.1

0.7 ± 0.2*

1.1 ± 0.1

0.8 ± 0.3

1.0 ± 0.07

1.1 ± 0.06

12 h

2.1 ± 0.04**

1.4 ± 0.1

0.6 ± 0.2**

1.1 ± 0.1

1.2 ± 0.03*

0.9 ± 0.09

1.1 ± 0.04

24 h

2.3 ± 0.05**

3.4 ± 0.3**

1.8 ± 0.09**

1.7 ± 0.04**

2.1 ± 0.07**

1.8 ± 0.4

1.3 ± 0.04*

48 h

1.6 ± 0.07**

2.6 ± 0.2**

1.0 ± 0.1

1.5 ± 0.01*

2.2 ± 0.08**

1.1 ± 0.05

1.2 ± 0.05