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Table 4 pKD values for clobenproprit and thioperamide

From: Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells

  pKD   pKD  
agonist clobenpropit n thioperamide n
histamine 9.38 ± 0.12 5 7.38 ± 0.04 4
N-α-methylhistamine 9.43 ± 0.14 5 7.28 ± 0.06 3
R-α-methylhistamine 9.36 ± 0.08 4 7.42 ± 0.09 3
S-α-methylhistamine 9.46 ± 0.08 4 7.45 ± 0.09 3
imetit 9.28 ± 0.07 5 7.48 ± 0.13 4
immepip 9.34 ± 0.15 5 7.46 ± 0.14 4
immethridine 9.32 ± 0.14 5 7.46 ± 0.13 4
proxyfan 9.32 ± 0.03 5 7.33 ± 0.09 4
VUF 8430 9.42 ± 0.10 5 7.43 ± 0.09 4
impentamine 9.46 ± 0.11 4 7.54 ± 0.09 4
burimamide 9.25 ± 0.14 4 7.39 ± 0.12 4
VUF 5681 9.20 ± 0.09 4 7.45 ± 0.10 4
  1. pKD values for clobenpropit and thioperamide as determined from 3H-cAMP accumulation measurements made in the presence of the 12 different agonists. Values represent mean ± s.e.mean of n separate experiments.