Table 1 pIC₅₀ values for H3 agonism

histamine

8.55 ± 0.05

12

7.89 ± 0.04

19

N-α-methylhistamine

9.45 ± 0.05

5

8.89 ± 0.04

17

R-α-methylhistamine

9.54 ± 0.06

4

8.94 ± 0.04

16

S-α-methylhistamine

8.31 ± 0.01

5

7.82 ± 0.06

17

imetit

9.91 ± 0.05

5

9.36 ± 0.04

16

immepip

10.30 ± 0.14

5

9.65 ± 0.03

15

immethridine

9.76 ± 0.08

5

9.41 ± 0.04

10

proxyfan

8.31 ± 0.11

5

7.79 ± 0.06

10

VUF 8430

6.38 ± 0.07

6

5.66 ± 0.08

8

Impentamine*

8.43 ± 0.08

5

Site 1 7.59 ± 0.05

8

Site 2 5.40 ± 0.05

8

burimamide

6.65 ± 0.10

5

6.37 ± 0.11

6

VUF 5681

8.41 ± 0.10

5

7.60 ± 0.13

5