Table 1 Phenotype of db/db mice
From: RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice
Lean litter mates | db/db mice | |
|---|---|---|
Body weight (g) | 24.1 ± 0.6 | 39.8 ± 0.5** |
Blood | ||
Glucose (mg/dL) | 120.1 ± 4.6 | 319.9 ± 37.5** |
HbA1c (%) | 3.2 ± 0.2 | 5.4 ± 0.6** |
Serum | ||
Insulin (ng/ml) | 0.3 ± 0.1 | 12.6 ± 2.9** |
Total cholesterol (mg/dL) | 73.8 ± 1.8 | 127 ± 3.2** |
Triglycerides (mg/dL) | 125.4 ± 15.8 | 200.9 ± 19.5** |
IL-6 (pg/ml) | 40.1 ± 4.5 | 61.8 ± 8.6* |
MCP-1 (pg/ml) | 34.4 ± 5.0 | 32.4 ± 1.0 |
TNFα | BQL | BQL |
IL-1β | BQL | BQL |
Corticosterone (ng/ml) | 45.7 ± 17.8 | 615 ± 36.4** |
ACTH (ng/ml) | 2.9 ± 0.4 | 2.4 ± 0.5 |