Antidepressant drugs modulate growth factors in cultured cells

BMC Pharmacology

Table 1 Statistical significance analysis

	2 days	7 days	14 days		2 days	7 days	14 days
	NGF				NT-3
Amitryptiline	< 0.0001	n.s.	n.s.	Amitryptiline	< 0.0001	n.s.	0.0001
Fluoxetine	< 0.0001	n.s.	n.s.	Fluoxetine	< 0.0001	n.s.	0.0017
Tranylcypromine	0.0014	n.s.	0.0032	Tranylcypromine	< 0.0001	n.s.	0.0002
Reboxetine	< 0.0001	n.s.	n.s.	Reboxetine	0.0004	0.0027	0.0001
	bFGF				Leptin
Amitryptiline	0.0012	n.s.	< 0.0001	Amitryptiline	< 0.0001	< 0.0001	0.0003
Fluoxetine	< 0.0001	n.s.	< 0.0001	Fluoxetine	n.s.	< 0.0001	< 0.0001
Tranylcypromine	0.004	< 0.0001	n.s.	Tranylcypromine	n.s.	< 0.0001	< 0.0001
Reboxetine	< 0.0001	n.s.	< 0.0001	Reboxetine	n.s.	0.0021	< 0.0001
	CNTF				CREB
Amitryptiline	n.s.	0.0003	< 0.0001	Amitryptiline	n.s.	< 0.0001	n.s.
Fluoxetine	0.001	< 0.0001	< 0.0001	Fluoxetine	n.s.	n.s.	n.s.
Tranylcypromine	0.002	< 0.0001	< 0.0001	Tranylcypromine	0.0001	< 0.0001	n.s.
Reboxetine	n.s.	< 0.0001	< 0.0001	Reboxetine	< 0.0001	< 0.0001	0.0002
	GDNF			--	BDNF
Amitryptiline	0.001	< 0.0001	0.005	Amitryptiline	n.s.	n.s.	0.002
Fluoxetine	< 0.0001	< 0.0001	0.0003	Fluoxetine	0.0005	0.0012	n.s.
Tranylcypromine	< 0.0001	n.s.	0.0009	Tranylcypromine	n.s.	0.0007	n.s.
Reboxetine	n.s.	n.s.	0.0006	Reboxetine	< 0.0001	n.s.	0.0017

Expressions of growth factors were tested with Student's t-test against the corresponding expression levels at the start of the experiments. Expression levels of controls, which were treated for 10 days with PMA, were normalized before testing. The values in the table represent the p-values, obtained by the t-test. The significance level was set at α = 0.004.