A global view of drug-therapy interactions

BMC Pharmacology

Table 1 Top-20 drugs with highest betweenness centrality in the drug network projection corresponding to level 2 of the ATC hierarchical classification. The associated therapy classes as well as closeness centrality, node degree and number of targets are also displayed.

Accession Id	Generic name	Therapy classes	B_icentrality	C_icentrality	Degree	Number of targets
APRD00616	Scopolamine	A04, N05, S01	0.0841	0.469	155	1
APRD00215	Morphine	G04, N02, N04, R05, S01	0.0549	0.479	164	1
APRD00362	Tretinoin	D10, L01	0.0420	0.365	80	3
APRD01080	Magnesium Sulfate	A06, A12, B05, D11, V04	0.0412	0.361	24	3
APRD00373	Celecoxib	L01, M01	0.0340	0.356	94	1
APRD00047	R-mephobarbital	N03, N05	0.0294	0.336	81	1
APRD00406	Physostigmine	S01, V03	0.0261	0.454	106	1
APRD00807	Atropine	A03, N04, S01	0.0251	0.460	126	5
APRD00479	Lidocaine	C01, C05, D04, N01, R02, S01, S02	0.0229	0.470	166	2
APRD00450	Epinephrine	A01, B02, C01, R01, R03, S01	0.0216	0.472	158	3
APRD00097	Orphenadrine	M03, N04	0.0213	0.334	38	5
APRD00267	Tolbutamide	A10, V04	0.0190	0.269	27	2
APRD01022	Hydroxocobalamin	B03, V03	0.0190	0.325	16	8
APRD00013	Neomycin	A01, A07, B05, D06, J01, R02, S01, S02, S03	0.0189	0.488	187	2
APRD00056	Heparin	B01, C05, S01	0.0188	0.454	121	3
APRD00174	Clonidine	C02, N02, S01	0.0185	0.461	136	1
APRD00326	Vitamin B12	A11, B03	0.0167	0.248	12	7
APRD00536	Vitamin B3	C04, C10	0.0167	0.269	21	8
APRD00650	Procaine	C05, D04, J01, N01, S01	0.0164	0.478	199	5
APRD00862	Chloramphenicol	D06, D10, G01, J01, S01, S02, S03	0.0157	0.496	184	1