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Table 1 Top-20 drugs with highest betweenness centrality in the drug network projection corresponding to level 2 of the ATC hierarchical classification. The associated therapy classes as well as closeness centrality, node degree and number of targets are also displayed.

From: A global view of drug-therapy interactions

Accession Id Generic name Therapy classes B i centrality C i centrality Degree Number of targets
APRD00616 Scopolamine A04, N05, S01 0.0841 0.469 155 1
APRD00215 Morphine G04, N02, N04, R05, S01 0.0549 0.479 164 1
APRD00362 Tretinoin D10, L01 0.0420 0.365 80 3
APRD01080 Magnesium Sulfate A06, A12, B05, D11, V04 0.0412 0.361 24 3
APRD00373 Celecoxib L01, M01 0.0340 0.356 94 1
APRD00047 R-mephobarbital N03, N05 0.0294 0.336 81 1
APRD00406 Physostigmine S01, V03 0.0261 0.454 106 1
APRD00807 Atropine A03, N04, S01 0.0251 0.460 126 5
APRD00479 Lidocaine C01, C05, D04, N01, R02, S01, S02 0.0229 0.470 166 2
APRD00450 Epinephrine A01, B02, C01, R01, R03, S01 0.0216 0.472 158 3
APRD00097 Orphenadrine M03, N04 0.0213 0.334 38 5
APRD00267 Tolbutamide A10, V04 0.0190 0.269 27 2
APRD01022 Hydroxocobalamin B03, V03 0.0190 0.325 16 8
APRD00013 Neomycin A01, A07, B05, D06, J01, R02, S01, S02, S03 0.0189 0.488 187 2
APRD00056 Heparin B01, C05, S01 0.0188 0.454 121 3
APRD00174 Clonidine C02, N02, S01 0.0185 0.461 136 1
APRD00326 Vitamin B12 A11, B03 0.0167 0.248 12 7
APRD00536 Vitamin B3 C04, C10 0.0167 0.269 21 8
APRD00650 Procaine C05, D04, J01, N01, S01 0.0164 0.478 199 5
APRD00862 Chloramphenicol D06, D10, G01, J01, S01, S02, S03 0.0157 0.496 184 1