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Table 3 Effect of CsA and sulphated polysaccharides on the levels of LPO, 8-OHdG and protein carbonyls

From: Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats

Parameters

Group I (Control)

Group II (CsA)

Group III (Sulphated polysaccharides)

Group IV (CsA + sulphated polysaccharides)

LPO

1.42 ± 0.14

3.89 ± 0.43 a***

1.38 ± 0.17

1.75 ± 0.17 a*b***

8-OHdG

11.59 ± 1.04

21.25 ± 3.24 a***

11.48 ± 1.26

15.76 ± 2.25 a**b***

Protein carbonyls

1.76 ± 0.16

3.38 ± 0.41 a***

1.73 ± 0.19

2.12 ± 0.26 a*b***

  1. Values are expressed as mean ± S.D. for six animals in each group.
  2. Units: LPO: nmoles of MDA formed/min/mg protein; 8-OHdG: fmoles of 8-OHdG/μg of nuclear DNA; Protein carbonyls: μg/mg protein.
  3. Comparisons are made between: a-Group I and Groups II, III, IV; b-Group II and Group IV. The symbols (***), (**) and (*) represent statistical significance at P < 0.001, P < 0.01 and P < 0.05, respectively.
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BMC Pharmacology

ISSN: 1471-2210