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Table 1 Effect of CsA and sulphated polysaccharides on hepatic marker enzymes

From: Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats

Enzyme parameters

Group I (Control)

Group II (CsA)

Group III (Sulphated polysaccharides)

Group IV (CsA + sulphated polysaccharides)

AST

0.22 ± 0.02

0.14 ± 0.01 a***

0.23 ± 0.03

0.19 ± 0.02 a*b***

ALT

0.18 ± 0.02

0.09 ± 0.01 a***

0.17 ± 0.02

0.15 ± 0.02 a*b***

LDH

11.57 ± 1.40

6.83 ± 0.75 a***

11.52 ± 1.13

10.22 ± 1.23 b***

ALP

1.58 ± 0.19

1.25 ± 0.15 a**

1.60 ± 0.19

1.54 ± 0.15 b**

  1. Values are expressed as mean ± S.D. for six animals in each group.
  2. Units: AST, ALT – μmoles × 10-2 of pyruvate liberated/min/mg protein; LDH – μmoles × 10-1 of pyruvate liberated/min/mg protein; ALP – μmoles × 10-2 of phenol liberated/min/mg protein.
  3. Comparisons are made between: a – Group I and Groups II, III, IV; b – Group II and Group IV. The symbols (***), (**) and (*) represent statistical significance at P < 0.001, P < 0.01 and P < 0.05, respectively.
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BMC Pharmacology

ISSN: 1471-2210