TY - JOUR AU - Josephine, Anthony AU - Nithya, Kalaiselvam AU - Amudha, Ganapathy AU - Veena, Coothan Kandaswamy AU - Preetha, Sreenivasan P. AU - Varalakshmi, Palaninathan PY - 2008 DA - 2008/02/20 TI - Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats JO - BMC Pharmacology SP - 4 VL - 8 IS - 1 AB - Seaweeds or marine algae have long been made up a key part of the Asian diet, and as an antioxidant, sulphated polysaccharides have piqued the interest of many researchers as one of the ocean's greatest treasures. The present investigation suggests the therapeutic potential of sulphated polysaccharides from marine brown algae "Sargassum wightii" in Cyclosporine A (CsA)- induced liver injury. CsA is a potent immunosuppressive agent used in the field of organ transplantations and various autoimmune disorders. However, hepatotoxicity due to CsA remains to be one of the major clinical challenges. SN - 1471-2210 UR - https://doi.org/10.1186/1471-2210-8-4 DO - 10.1186/1471-2210-8-4 ID - Josephine2008 ER -