Table 1 Effect of 10-day treatment on various metabolic parameters
Vehicle | 3 mg/kg | 10 mg/kg | 30 mg/kg | Rosiglitazone | |
|---|---|---|---|---|---|
Food Intake (g) | 47.8 ± 2.2 | 48.6 ± 2.3 | 51.1 ± 1.9 | 42.9 ± 1.3 | 50.6 ± 1.2 |
Body Weight (g) | 39.9 ± 0.7 | 42.9 ± 1.2 | 41.2 ± 1.0 | 43.5 ± 1.3 | 45.0 ± 1.0** |
Body Weight as percent of initial (%) | 96.4 ± 1.0 | 98.0 ± 0.7 | 98.1 ± 0.5 | 100.4 ± 0.1 | 107.3 ± 1.2** |
Initial body weight (g) | 41.4 ± 0.8 | 43.8 ± 1.2 | 41.9 ± 0.8 | 43.3 ± 1.3 | 41.9 ± 0.68 |
Fat Pad weight (g) | 1.60 ± 0.07 | 1.72 ± 0.05 | 1.55 ± 0.04 | 1.50 ± 0.07 | 1.68 ± 0.07 |
Fat pad/body weight ×100 | 4.02 ± 0.18 | 4.03 ± 0.19 | 3.77 ± 0.14 | 3.54 ± 0.23 | 3.74 ± 0.16 |
Leptin (ng/ml) | 57.2 ± 0.7 | 68.6 ± 4.5 | 59.4 ± 2.3 | 73.6 ± 3.1* | 83.6 ± 2.9*** |
Insulin (ng/ml) | 20.8 ± 5.2 | 23.6 ± 4.0 | 13.6 ± 4.6 | 17.7 ± 8.4 | 11.8 ± 2.5 |
Triglycerides (ng/ml) | 1.90 ± 0.18 | 2.29 ± 0.13 | 2.6 ± 0.46 | 3.03 ± 0.30 | 2.3 ± 0.29 |
Liver triglycerides (mg/g liver) | 14.7 ± 1.0 | 20.4 ± 3.0 | 15.2 ± 1.0 | 18.5 ± 1.4 | 20.9 ± 2.0 |
Total cholesterol (mM) | 4.0 ± 0.2 | 3.9 ± 0.1 | 4.0 ± 0.1 | 4.1 ± 0.2 | 5.1 ± 0.3** |
HDL cholesterol (mM) | 3.1 ± 0.2 | 3.0 ± 0.1 | 3.1 ± 0.1 | 3.2 ± 1.3 | 4.1 ± 0.2** |
Liver cholesterol (mg/g liver) | 4.0 ± 0.2 | 3.8 ± 0.2 | 4.3 ± 0.2 | 3.6 ± 0.1 | 3.2 ± 0.1* |