Figure 6

Secreted PGE2 levels after treatment of TPA-activated murine macrophage cells with substituted trans -stilbenes. BV-2 cells were activated with TPA and co-incubated with resveratrol, 1, 29, 46, or 48. Secreted PGE2 levels were quantified by competitive ELISA. Basal levels of secreted PGE2 were established using non-stimulated BV-2 cells (125 pg/ml). Maximal PGE2 levels were determined by treating BV-2 cells with TPA alone and no inhibitor (230 pg/ml). Analog 29 was the most potent inhibitor of PGE2 secretion. The * notation indicates p < 0.05.