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Table 2 Comparison of desipramine-treated and control rat rectal temperatures at various times after the last dose of desipramine in the 4-day treatment paradigm.

From: Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration

Adult Rats Postnatal Day 13 – 16 Rats
Time after last dose Control Desipramine Time after last dose Control Desipramine
14 h 34.4 ± 0.2 (4) 34.6 ± 0.4 (4) 14 h 34.2 ± 0.2 (3) 33.6 ± 0.2a (5)
24 h 34.4 ± 0.2 (12) 34.5 ± 0.1 (12) 24 h 33.9 ± 0.1 (14) 33.6 ± 0.2 (12)
48 h 35.3 ± 0.2 (14) 33.9 ± 0.1a (13) 63 h 35.3 ± 0.1 (11) 35.3 ± 0.3 (14)
96 h 34.7 ± 0.2 (8) 34.3 ± 0.1 (7) 96 h 35.0 ± 0.1 (13) 34.9 ± 0.2 (9)
  1. Juvenile rats received the last injection on post-natal day 12. A student t-test was used to compare the temperatures of the control versus the desipramine treated rats prior to giving brimonidine. Values are temperature in°C ± S.E.M. Number of rats in each group is given in parenthesis.
  2. aSignificantly different than control at P < 0.05