Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration

Table 1 Administration paradigms for brimonidine and RX821002 dose-response curves.

Age of rat at beginning of dosing	Drug 1	Dose (mg/kg)	Drug 2	Dose (mg/kg)	# of Rats
	Brimonidine	Dose	Response
65 to 75	Brimonidine in 10% DMSO	0	None		8
		0.1			6
		0.3			4
		0.6			8
		1.0			6
		1.5			7
		2			4
13	Brimonidine in 10% DMSO	0	None		4
		0.1			4
		0.3			4
		0.6			4
		0.8			4
		1.0			3
Antagonism of	Brimonidine	by	RX821002
65 to 75	RX821002 in water	0	Brimonidine in 10% DMSO	0	8
		0		1	10
		0.02		1	4
		0.05		1	4
		0.1		1	4
		0.1		0	2
13	RX821002 in water	0	Brimonidine in 10% DMSO	0.6	4
		0.02		0.6	4
		0.04		0.6	4
		0.08		0.6	4
		0.08		0	4

Drug solutions were prepared so that the adult rats received 0.1 ml/100 gm and the post-natal day 13 rats received 0.1 ml/20 gm. The control rats received the same solvent as used for preparing the drug.