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Table 1 Administration paradigms for brimonidine and RX821002 dose-response curves.

From: Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration

Age of rat at beginning of dosing Drug 1 Dose (mg/kg) Drug 2 Dose (mg/kg) # of Rats
  Brimonidine Dose Response   
65 to 75 Brimonidine in 10% DMSO 0 None   8
   0.1    6
   0.3    4
   0.6    8
   1.0    6
   1.5    7
   2    4
13 Brimonidine in 10% DMSO 0 None   4
   0.1    4
   0.3    4
   0.6    4
   0.8    4
   1.0    3
Antagonism of Brimonidine by RX821002   
65 to 75 RX821002 in water 0 Brimonidine in 10% DMSO 0 8
   0   1 10
   0.02   1 4
   0.05   1 4
   0.1   1 4
   0.1   0 2
13 RX821002 in water 0 Brimonidine in 10% DMSO 0.6 4
   0.02   0.6 4
   0.04   0.6 4
   0.08   0.6 4
   0.08   0 4
  1. Drug solutions were prepared so that the adult rats received 0.1 ml/100 gm and the post-natal day 13 rats received 0.1 ml/20 gm. The control rats received the same solvent as used for preparing the drug.