Figure 5
Brimonidine induced changes in rectal temperature after 4-day desipramine treatment in juvenile rats. Rats were injected twice a day for four days with water or 3 mg/kg desipramine (DMI) starting either the evening of post-natal day 8 or the morning of post-natal day 9. The measurements in rectal temperature were conducted the same time each morning 14, 24, 63, and 96 h after the last desipramine/water dose. The rectal temperature was taken immediately prior (0 time) to giving brimonidine (0.6 mg/kg) and then 45, 90 and 135 min thereafter. Data points are the average change in rectal temperature from the zero time temperature for each group of rats. The number of rats used in the 14, 24, 64 and 96 h studies was 3, 14, 11 and 13 control rats and 5, 12, 14 and 9 desipramine treated rats, respectively. The change in rectal temperature with time is statically significantly (P < 0.05) different for all experiments.