Methoxylation enhances stilbene bioactivity in Caenorhabditis elegans

Wilson, Mark A; Rimando, Agnes M; Wolkow, Catherine A

doi:10.1186/1471-2210-8-15

BMC Pharmacology

Table 1 Adult survival statistics for all trials.

From: Methoxylation enhances stilbene bioactivity in Caenorhabditis elegans

Trial	Concentration (μM)	Mean lifespan (days)		Relative survival (%)	p(Logrank)	n (failed, censor)
		Treated	Control
*Resveratrol-trimethylether*
1	100	9.7	12.16	80%	0.004	61,0
4	20	7.72	11.26	69%	< 0.001	61,0
4	40	7.72	11.26	69%	< 0.001	74,0
4	100	7.18	11.26	64%	< 0.001	70,2
5	5	18.83	18.49	102%	0.91	46,3
5	20	16.41	18.49	89%	0.055	42,3
5	100	15.18	18.49	82%	0.005	37,6
6	20	9.02	15.32	59%	< 0.0001	49,5
6	40	7.98	15.32	52%	< 0.0001	51,0
6	100	7.54	15.32	49%	< 0.0001	52,0
*3-OH-5,4'- dimethoxystilbene*
1	100	6.34	12.16	52%	< 0.0001	53,0
2	20	11.05	11.05	100%	0.986	47,2
2	40	10.52	11.05	95%	0.234	40,1
6	20	10.38	15.32	68%	< 0.0001	56,0
6	40	7.68	15.32	50%	< 0.0001	54,1
6	100	6.56	15.32	43%	< 0.0001	55,3
*Pterostilbene*
1	100	9.55	12.16	79%	0.005	69,9
4	20	10.43	11.26	93%	0.336	54,0
4	40	10	11.26	89%	0.035	65,1
4	100	8.07	11.26	72%	< 0.0001	51,1
6	20	13.72	15.32	90%	0.058	55,1
6	40	14.41	15.32	94%	0.142	51,4
6	100	10.98	15.32	72%	< 0.001	51,0
*Desoxyrhapontigenin*
1	100	10.64	12.16	88%	0.12	61,1
3	100	11.31	15.37	74%	< 0.0001	36,0
3	200	11.61	15.37	76%	< 0.0001	44,1
4	20	10.2	11.26	91%	0.12	74,0
4	40	10.38	11.26	92%	0.11	71,2
4	100	9.44	11.26	84%	0.003	50,0
6	20	14.18	15.32	93%	0.494	54,3
6	40	15.31	15.32	100%	0.48	59,1
6	100	13.63	15.32	89%	0.027	46,9
*Pinostilbene*
1	100	13.6	12.16	112%	0.062	68,1
2	20	10.04	11.05	91%	0.266	55,0
2	40	11.53	11.05	104%	0.319	42,5
3	100	16.9	15.37	110%	0.448	41,0
3	200	15.23	15.37	99%	0.411	42,5
6	20	14.24	15.32	93%	0.319	56,3
6	40	17.33	15.32	113%	0.085	60,0
6	100	16.24	15.32	106%	0.724	51,2
*Resveratrol*
1	100	12.18	12.16	100%	0.867	70,3
2	20	11.85	11.05	107%	0.182	48,4
2	40	10.53	11.05	95%	0.924	55,0
3	100	16.64	15.37	108%	0.435	30,4
3	200	17	15.37	111%	0.337	38,0
6	20	14.65	15.32	96%	0.804	54,5
6	40	16.17	15.32	106%	0.501	59,0
6	100	17.55	15.32	115%	0.055	58,0
*Piceatannol*
2	20	11.72	11.05	106%	0.362	44,0
2	40	11.58	11.05	105%	0.5	37,9
3	100	17.78	15.37	116%	0.094	55,1
3	200	17.5	15.37	114%	0.166	55,1
6	20	13.71	15.32	89%	0.231	50,1
6	40	15.63	15.32	102%	0.75	50,1
6	100	16.6	15.32	108%	0.146	50,1

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