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Table 1 Effect of Atorvastatin and Pitavastatin on L-Methionine induced changes in day 4 escape latency time (ELT), using Morris Water Maze.

From: Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats

Groups

Treatment

Dose (kg/day, p.o.)

ELT (day 1) in sec

ELT (day 4) in sec

I

Control

10 ml(0.5%w/w CMC)

81.5 ± 4.5

20.2 ± 2.2a

II

L-Methionine

1.7 g

93.8 ± 4.2

49.9 ± 2.4b

III

Atorvastatin per se

10 mg

85.5 ± 4.1

22.4 ± 3.4

IV

Pitavastatin per se

10 mg

82.3 ± 4.3

21.3 ± 3.8

V

L-Methionine + Atorvastatin

10 mg

81.9 ± 3.9

27.0 ± 2.4c

VI

L-Methionine + Pitavastatin

10 mg

82.5 ± 4.4

27.9 ± 3.6c

  1. Each group (n = 10), represent mean ± SEM.
  2. a = p < 0.01 Day 1 Vs Day 4 ELT in vehicle control.
  3. b = p < 0.05 Vs Day 4 ELT in vehicle control.
  4. c = p < 0.05 Vs Day 4 ELT in L-Methionine treated group.