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Table 1 Effect of Atorvastatin and Pitavastatin on L-Methionine induced changes in day 4 escape latency time (ELT), using Morris Water Maze.

From: Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats

Groups Treatment Dose (kg/day, p.o.) ELT (day 1) in sec ELT (day 4) in sec
I Control 10 ml(0.5%w/w CMC) 81.5 ± 4.5 20.2 ± 2.2a
II L-Methionine 1.7 g 93.8 ± 4.2 49.9 ± 2.4b
III Atorvastatin per se 10 mg 85.5 ± 4.1 22.4 ± 3.4
IV Pitavastatin per se 10 mg 82.3 ± 4.3 21.3 ± 3.8
V L-Methionine + Atorvastatin 10 mg 81.9 ± 3.9 27.0 ± 2.4c
VI L-Methionine + Pitavastatin 10 mg 82.5 ± 4.4 27.9 ± 3.6c
  1. Each group (n = 10), represent mean ± SEM.
  2. a = p < 0.01 Day 1 Vs Day 4 ELT in vehicle control.
  3. b = p < 0.05 Vs Day 4 ELT in vehicle control.
  4. c = p < 0.05 Vs Day 4 ELT in L-Methionine treated group.