Screen | Screening criteria | Fraction passing | Number passing |
---|---|---|---|
1 | Oral clearance, LD50, and all six cytotoxicity models | 0.0036 | 416 |
2 | Oral clearance, LD50, and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models | 0.0043 | 498 |
3 | LD50 and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models | 0.035 | 4,014 |
4 | Oral clearance and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models | 0.017 | 1,981 |
5 | Oral clearance, LD50, and passing in both H460 models | 0.0045 | 520 |
6 | Oral clearance and passing in both H460 models | 0.039 | 4,458 |
7 | LD50 and passing in both H460 models | 0.022 | 2,255 |
8 | Passing both H460 models only | 0.24 | 27,608 |