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Table 4 Summary of screening results

From: Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compounds

Screen Screening criteria Fraction passing Number passing
1 Oral clearance, LD50, and all six cytotoxicity models 0.0036 416
2 Oral clearance, LD50, and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models 0.0043 498
3 LD50 and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models 0.035 4,014
4 Oral clearance and passing in both H460 models and both LC50 and TGI of either MCF7 or SF-268 models 0.017 1,981
5 Oral clearance, LD50, and passing in both H460 models 0.0045 520
6 Oral clearance and passing in both H460 models 0.039 4,458
7 LD50 and passing in both H460 models 0.022 2,255
8 Passing both H460 models only 0.24 27,608